STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNEG_01143PLD phosphodiesterase domain-containing protein. (462 aa)    
Predicted Functional Partners:
PNEG_00379
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.936
PNEG_03202
Ku domain-containing protein.
     
 0.810
PNEG_01255
VWFA domain-containing protein.
    
 0.800
PNEG_01944
DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.
   
 
 0.781
PNEG_03555
ERCC4 domain-containing protein.
   
 
 0.780
PNEG_00580
ERCC4 domain-containing protein.
   
 
 0.769
PNEG_03217
Uncharacterized protein.
   
  
 0.753
PNEG_00889
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
   
 
 0.744
PNEG_00153
Uncharacterized protein.
    
 
 0.729
PNEG_00477
Uncharacterized protein.
 
 
 
 0.724
Your Current Organism:
Pneumocystis murina
NCBI taxonomy Id: 1069680
Other names: P. murina B123, Pneumocystis murina B123
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