PNEG_03043 protein (Pneumocystis murina) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

PNEG_03043

Uncharacterized protein. (375 aa)

Predicted Functional Partners:

PNEG_03526

0.994

PNEG_02067

0.992

PNEG_03547

0.992

PNEG_03025

0.992

PNEG_04304

0.990

PNEG_02860

0.990

PNEG_02316

0.990

PNEG_02194

0.990

PNEG_02822

0.990

PNEG_03396

0.988

Your Current Organism:

Pneumocystis murina

NCBI taxonomy Id: 1069680
Other names: P. murina B123, Pneumocystis murina B123

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PNEG_02067	PNEG_02194	M7P6H6	M7NR68	PCI domain-containing protein.	PCI domain-containing protein.	0.999
PNEG_02067	PNEG_02316	M7P6H6	M7NQJ3	PCI domain-containing protein.	26S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.997
PNEG_02067	PNEG_02822	M7P6H6	M7P594	PCI domain-containing protein.	VWFA domain-containing protein.	0.999
PNEG_02067	PNEG_02860	M7P6H6	M7NN76	PCI domain-containing protein.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.999
PNEG_02067	PNEG_03025	M7P6H6	M7PDK4	PCI domain-containing protein.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
PNEG_02067	PNEG_03043	M7P6H6	M7P3X7	PCI domain-containing protein.	Uncharacterized protein.	0.992
PNEG_02067	PNEG_03396	M7P6H6	M7NI43	PCI domain-containing protein.	Proteasome subunit alpha type.	0.995
PNEG_02067	PNEG_03526	M7P6H6	M7NLS1	PCI domain-containing protein.	MPN domain-containing protein.	0.999
PNEG_02067	PNEG_03547	M7P6H6	M7PCA5	PCI domain-containing protein.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.999
PNEG_02067	PNEG_04304	M7P6H6	A0A0W4ZWY9	PCI domain-containing protein.	26S protease regulatory subunit 8.	0.999
PNEG_02194	PNEG_02067	M7NR68	M7P6H6	PCI domain-containing protein.	PCI domain-containing protein.	0.999
PNEG_02194	PNEG_02316	M7NR68	M7NQJ3	PCI domain-containing protein.	26S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.998
PNEG_02194	PNEG_02822	M7NR68	M7P594	PCI domain-containing protein.	VWFA domain-containing protein.	0.998
PNEG_02194	PNEG_02860	M7NR68	M7NN76	PCI domain-containing protein.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.998
PNEG_02194	PNEG_03025	M7NR68	M7PDK4	PCI domain-containing protein.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.998
PNEG_02194	PNEG_03043	M7NR68	M7P3X7	PCI domain-containing protein.	Uncharacterized protein.	0.990
PNEG_02194	PNEG_03396	M7NR68	M7NI43	PCI domain-containing protein.	Proteasome subunit alpha type.	0.997
PNEG_02194	PNEG_03526	M7NR68	M7NLS1	PCI domain-containing protein.	MPN domain-containing protein.	0.999
PNEG_02194	PNEG_03547	M7NR68	M7PCA5	PCI domain-containing protein.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.999
PNEG_02194	PNEG_04304	M7NR68	A0A0W4ZWY9	PCI domain-containing protein.	26S protease regulatory subunit 8.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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