PNEG_02223 protein (Pneumocystis murina) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

PNEG_02223

Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (317 aa)

Predicted Functional Partners:

PNEG_01371

0.907

PNEG_02889

0.904

PNEG_02879

0.883

PNEG_01337

0.792

PNEG_01291

0.743

PNEG_02090

0.725

PNEG_03120

0.712

PNEG_00781

0.710

PNEG_01165

0.682

PNEG_02961

0.652

Your Current Organism:

Pneumocystis murina

NCBI taxonomy Id: 1069680
Other names: P. murina B123, Pneumocystis murina B123

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PNEG_00781	PNEG_02090	M7NR43	M7NQF6	Uncharacterized protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.661
PNEG_00781	PNEG_02223	M7NR43	M7P6X4	Uncharacterized protein.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.710
PNEG_01165	PNEG_01337	M7P9B6	M7NU41	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	0.619
PNEG_01165	PNEG_02090	M7P9B6	M7NQF6	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.761
PNEG_01165	PNEG_02223	M7P9B6	M7P6X4	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.682
PNEG_01291	PNEG_02090	M7NTZ2	M7NQF6	DUF2428 domain-containing protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.997
PNEG_01291	PNEG_02223	M7NTZ2	M7P6X4	DUF2428 domain-containing protein.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.743
PNEG_01291	PNEG_03120	M7NTZ2	M7NNE9	DUF2428 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.976
PNEG_01337	PNEG_01165	M7NU41	M7P9B6	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.	0.619
PNEG_01337	PNEG_02090	M7NU41	M7NQF6	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.827
PNEG_01337	PNEG_02223	M7NU41	M7P6X4	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.792
PNEG_01337	PNEG_02879	M7NU41	M7NNJ6	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.625
PNEG_01337	PNEG_03120	M7NU41	M7NNE9	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	WD_REPEATS_REGION domain-containing protein.	0.482
PNEG_01371	PNEG_02223	M7NTS2	M7P6X4	Serine-tRNA ligase.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.907
PNEG_01371	PNEG_02889	M7NTS2	M7NNK8	Serine-tRNA ligase.	Serine-tRNA ligase.	0.906
PNEG_02090	PNEG_00781	M7NQF6	M7NR43	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Uncharacterized protein.	0.661
PNEG_02090	PNEG_01165	M7NQF6	M7P9B6	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.	0.761
PNEG_02090	PNEG_01291	M7NQF6	M7NTZ2	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	DUF2428 domain-containing protein.	0.997
PNEG_02090	PNEG_01337	M7NQF6	M7NU41	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	0.827
PNEG_02090	PNEG_02223	M7NQF6	M7P6X4	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.	0.725

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.91

expected number of edges:

23

PPI enrichment p-value:

0.0464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

7 of 93

1.29

1.5

1.43e-05

GO:0010467

Gene expression

8 of 188

1.05

1.11

1.43e-05

GO:0034641

Cellular nitrogen compound metabolic process

8 of 530

0.6

0.42

0.0104

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

6 of 46

1.53

1.94

5.83e-06

GO:0032977

Membrane insertase activity

2 of 2

2.42

1.13

0.0083

GO:0003723

RNA binding

5 of 92

1.15

0.9

0.0027

GO:0019843

rRNA binding

3 of 34

1.36

0.74

0.0225

GO:0003676

Nucleic acid binding

7 of 323

0.75

0.53

0.0070

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

7 of 52

1.55

2.47

2.86e-08

GO:0005622

Intracellular anatomical structure

8 of 817

0.41

0.28

0.0446

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23342046

(2013) The genome sequences of Cellulomonas fimi and Cellvibrio gilvus reveal the cellulolytic strategies of two facultative anaerobes, transfer of Cellvibrio gilvus to the genus Cellulomonas, and proposal of Cellulomonas gilvus sp. nov.

4 of 28

1.57

1.45

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:153

Structural constituent of ribosome

7 of 55

1.52

2.41

2.92e-08

CL:136

Translation, and Protein export

10 of 118

1.34

2.24

1.40e-10

CL:155

Structural constituent of ribosome

6 of 50

1.5

2.09

6.88e-07

CL:141

Ribosome, and Translation regulator activity

8 of 91

1.36

2.05

1.74e-08

CL:156

Structural constituent of ribosome

5 of 44

1.47

1.74

1.82e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fsc03010

Ribosome

7 of 47

1.59

2.62

1.68e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

6 of 35

1.65

2.4

5.38e-07

GOCC:0043229

Intracellular organelle

7 of 205

0.95

0.89

0.00015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 49

1.57

2.5

4.01e-08

KW-0694

RNA-binding

4 of 60

1.24

0.92

0.0039

KW-0699

rRNA-binding

3 of 31

1.4

0.88

0.0105

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