PNEG_00117 protein (Pneumocystis murina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

PNEG_00117

Uncharacterized protein. (359 aa)

Predicted Functional Partners:

PNEG_00809

0.983

PNEG_00477

0.828

PNEG_00568

0.682

PNEG_00163

0.618

PNEG_01245

0.590

PNEG_01054

0.585

PNEG_02002

0.576

PNEG_03361

0.569

PNEG_03132

0.501

PNEG_03131

0.501

Your Current Organism:

Pneumocystis murina

NCBI taxonomy Id: 1069680
Other names: P. murina B123, Pneumocystis murina B123

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PNEG_00117	PNEG_00163	M7PCP3	M7PMN8	Uncharacterized protein.	40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.618
PNEG_00117	PNEG_00477	M7PCP3	M7PC40	Uncharacterized protein.	Uncharacterized protein.	0.828
PNEG_00117	PNEG_00568	M7PCP3	M7PKI0	Uncharacterized protein.	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.	0.682
PNEG_00117	PNEG_00809	M7PCP3	M7PBG1	Uncharacterized protein.	Uncharacterized protein.	0.983
PNEG_00117	PNEG_01054	M7PCP3	M7NQB5	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2-20 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.585
PNEG_00117	PNEG_01245	M7PCP3	M7NTC7	Uncharacterized protein.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.590
PNEG_00117	PNEG_02002	M7PCP3	M7NRU9	Uncharacterized protein.	Uncharacterized protein.	0.576
PNEG_00117	PNEG_03131	M7PCP3	M7NN52	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.501
PNEG_00117	PNEG_03132	M7PCP3	M7NJ62	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.501
PNEG_00117	PNEG_03361	M7PCP3	M7P2V1	Uncharacterized protein.	WHIM1 domain-containing protein.	0.569
PNEG_00163	PNEG_00117	M7PMN8	M7PCP3	40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.618
PNEG_00163	PNEG_01245	M7PMN8	M7NTC7	40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999
PNEG_00477	PNEG_00117	M7PC40	M7PCP3	Uncharacterized protein.	Uncharacterized protein.	0.828
PNEG_00477	PNEG_00809	M7PC40	M7PBG1	Uncharacterized protein.	Uncharacterized protein.	0.999
PNEG_00477	PNEG_03131	M7PC40	M7NN52	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.990
PNEG_00477	PNEG_03132	M7PC40	M7NJ62	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.997
PNEG_00568	PNEG_00117	M7PKI0	M7PCP3	Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.	Uncharacterized protein.	0.682
PNEG_00809	PNEG_00117	M7PBG1	M7PCP3	Uncharacterized protein.	Uncharacterized protein.	0.983
PNEG_00809	PNEG_00477	M7PBG1	M7PC40	Uncharacterized protein.	Uncharacterized protein.	0.999
PNEG_00809	PNEG_02002	M7PBG1	M7NRU9	Uncharacterized protein.	Uncharacterized protein.	0.617

page 1 of 2

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.528

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

3 of 6

2.84

2.45

3.26e-05

GO:0022900

Electron transport chain

4 of 36

2.19

2.29

3.26e-05

GO:0032981

Mitochondrial respiratory chain complex I assembly

2 of 7

2.6

1.34

0.0035

GO:0006979

Response to oxidative stress

2 of 20

2.14

0.93

0.0181

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

6 of 9

2.97

6.84

1.59e-13

GO:0051539

4 iron, 4 sulfur cluster binding

2 of 44

1.8

0.71

0.0427

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

8 of 11

3.01

9.98

1.07e-19

GO:0031967

Organelle envelope

9 of 262

1.68

3.74

4.24e-13

GO:0031090

Organelle membrane

9 of 714

1.25

1.85

1.89e-09

GO:0032991

Protein-containing complex

9 of 1641

0.88

0.92

2.51e-06

GO:0043231

Intracellular membrane-bounded organelle

10 of 4434

0.5

0.41

0.00084

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14344

NADH dehydrogenase complex, and 4Fe-4S binding domain

9 of 13

2.98

11.19

3.07e-22

CL:14332

Respirasome, and Protein processing involved in protein targeting to mitochondrion

10 of 34

2.61

10.25

3.07e-22

CL:14346

Mitochondrial electron transport, NADH to ubiquinone, and 4Fe-4S binding domain

6 of 8

3.02

7.53

8.20e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 91

2.14

6.46

1.07e-16

map01100

Metabolic pathways

10 of 2785

0.7

0.64

2.44e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

9 of 19

2.82

10.44

2.36e-21

MAP-611105

Respiratory electron transport

9 of 37

2.53

8.85

1.88e-19

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

9 of 43

2.47

8.5

4.18e-19

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

9 of 103

2.09

6.06

4.65e-16

MAP-1430728

Metabolism

10 of 1459

0.98

1.15

1.02e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 26

2.57

6.75

3.02e-14

GOCC:0030964

NADH dehydrogenase complex

5 of 6

3.07

5.9

1.29e-11

GOCC:0005747

Mitochondrial respiratory chain complex I

4 of 5

3.05

4.52

5.14e-09

GOCC:0005743

Mitochondrial inner membrane

5 of 116

1.78

2.5

1.19e-06

GOCC:0005740

Mitochondrial envelope

6 of 191

1.64

2.49

1.95e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 4

2.84

1.54

0.0016

KW-0999

Mitochondrion inner membrane

2 of 23

2.08

1.05

0.0104

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