STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrBUvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] (697 aa)    
Predicted Functional Partners:
uvrA
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.998
uvrD
DNA helicase II; Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme.
  
 
 0.928
CCD30230.1
Putative Histidine kinase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme.
   
 
 0.812
mfd
Transcription-repair-coupling factor (TRCF) (ATP-dependent helicase Mfd); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
    
0.729
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
       0.707
CCD30067.1
Sensor protein; Evidence 2b:Function of strongly homologous gene; Product type e:enzyme.
     
 0.695
pheT
Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS); Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.678
guaA
GMP synthase (glutamine-hydrolyzing) (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP.
     
 0.670
CCD29160.1
Hypothetical protein; Evidence 5:No homology to any previously reported sequences.
       0.648
hprK
HPr kinase/phosphorylase (HPrK/P) (HPr(Ser) kinase/phosphorylase) HprK; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
    
 0.628
Your Current Organism:
Glomeribacter gigasporarum
NCBI taxonomy Id: 1070319
Other names: C. Glomeribacter gigasporarum BEG34, Candidatus Glomeribacter gigasporarum BEG34, Candidatus Glomeribacter gigasporarum str. BEG34, Candidatus Glomeribacter gigasporarum strain BEG34
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