node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bfd | lpxB | CAGGBEG34_250039 | CAGGBEG34_250043 | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.577 |
bfd | metG | CAGGBEG34_250039 | CAGGBEG34_250041 | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.615 |
bfd | murI | CAGGBEG34_250039 | CAGGBEG34_250040 | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.615 |
bfd | rnhB | CAGGBEG34_250039 | CAGGBEG34_250042 | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | Ribonuclease HII (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.577 |
gdhA | guaB | CAGGBEG34_210078 | CAGGBEG34_180088 | Fragment of putative 3-dehydroquinate synthase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.588 |
gdhA | murI | CAGGBEG34_210078 | CAGGBEG34_250040 | Fragment of putative 3-dehydroquinate synthase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.677 |
gdhA | nadE | CAGGBEG34_210078 | CAGGBEG34_200109 | Fragment of putative 3-dehydroquinate synthase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamine-dependent NAD(+) synthetase (NAD(+) synthase (glutamine-hydrolyzing)) (NadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.885 |
gdhA | purL | CAGGBEG34_210078 | CAGGBEG34_260001 | Fragment of putative 3-dehydroquinate synthase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme. | 0.844 |
guaB | gdhA | CAGGBEG34_180088 | CAGGBEG34_210078 | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Fragment of putative 3-dehydroquinate synthase; Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.588 |
guaB | metG | CAGGBEG34_180088 | CAGGBEG34_250041 | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.728 |
guaB | murI | CAGGBEG34_180088 | CAGGBEG34_250040 | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.606 |
guaB | nadE | CAGGBEG34_180088 | CAGGBEG34_200109 | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glutamine-dependent NAD(+) synthetase (NAD(+) synthase (glutamine-hydrolyzing)) (NadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.804 |
guaB | purL | CAGGBEG34_180088 | CAGGBEG34_260001 | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme. | 0.911 |
lpxB | bfd | CAGGBEG34_250043 | CAGGBEG34_250039 | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | 0.577 |
lpxB | metG | CAGGBEG34_250043 | CAGGBEG34_250041 | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.781 |
lpxB | murI | CAGGBEG34_250043 | CAGGBEG34_250040 | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.736 |
lpxB | purL | CAGGBEG34_250043 | CAGGBEG34_260001 | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme. | 0.485 |
lpxB | rnhB | CAGGBEG34_250043 | CAGGBEG34_250042 | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Ribonuclease HII (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.992 |
metG | bfd | CAGGBEG34_250041 | CAGGBEG34_250039 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | BFD domain protein (2Fe-2S)-binding domain protein; Evidence 2b:Function of strongly homologous gene; Product type c:carrier. | 0.615 |
metG | guaB | CAGGBEG34_250041 | CAGGBEG34_180088 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.728 |