AFS01080.1 protein (Lactobacillus buchneri CD034)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

AFS01080.1

Putative acyl-CoA thioester hydrolase. (174 aa)

Predicted Functional Partners:

AFS01079.1

0.566

AFS00345.1

0.565

AFS01081.1

0.527

AFS00664.1

0.479

AFR99289.1

0.450

fabI

0.418

Your Current Organism:

Lactobacillus buchneri CD034

NCBI taxonomy Id: 1071400
Other names: L. buchneri CD034, Lactobacillus buchneri str. CD034, Lactobacillus buchneri strain CD034

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFR99289.1	AFS01080.1	LBUCD034_0181	LBUCD034_2097	Multimeric flavodoxin.	Putative acyl-CoA thioester hydrolase.	0.450
AFS00345.1	AFS00664.1	LBUCD034_1307	LBUCD034_1648	Uncharacterized protein conserved in bacteria.	Lipoate--protein ligase A.	0.774
AFS00345.1	AFS01080.1	LBUCD034_1307	LBUCD034_2097	Uncharacterized protein conserved in bacteria.	Putative acyl-CoA thioester hydrolase.	0.565
AFS00664.1	AFS00345.1	LBUCD034_1648	LBUCD034_1307	Lipoate--protein ligase A.	Uncharacterized protein conserved in bacteria.	0.774
AFS00664.1	AFS01080.1	LBUCD034_1648	LBUCD034_2097	Lipoate--protein ligase A.	Putative acyl-CoA thioester hydrolase.	0.479
AFS01079.1	AFS01080.1	LBUCD034_2096	LBUCD034_2097	Putative universal stress protein.	Putative acyl-CoA thioester hydrolase.	0.566
AFS01080.1	AFR99289.1	LBUCD034_2097	LBUCD034_0181	Putative acyl-CoA thioester hydrolase.	Multimeric flavodoxin.	0.450
AFS01080.1	AFS00345.1	LBUCD034_2097	LBUCD034_1307	Putative acyl-CoA thioester hydrolase.	Uncharacterized protein conserved in bacteria.	0.565
AFS01080.1	AFS00664.1	LBUCD034_2097	LBUCD034_1648	Putative acyl-CoA thioester hydrolase.	Lipoate--protein ligase A.	0.479
AFS01080.1	AFS01079.1	LBUCD034_2097	LBUCD034_2096	Putative acyl-CoA thioester hydrolase.	Putative universal stress protein.	0.566
AFS01080.1	AFS01081.1	LBUCD034_2097	LBUCD034_2098	Putative acyl-CoA thioester hydrolase.	Putative (R,R)-butanediol dehydrogenase.	0.527
AFS01080.1	fabI	LBUCD034_2097	LBUCD034_1729	Putative acyl-CoA thioester hydrolase.	Enoyl-[acyl-carrier-protein] reductase (NADH).	0.418
AFS01081.1	AFS01080.1	LBUCD034_2098	LBUCD034_2097	Putative (R,R)-butanediol dehydrogenase.	Putative acyl-CoA thioester hydrolase.	0.527
fabI	AFS01080.1	LBUCD034_1729	LBUCD034_2097	Enoyl-[acyl-carrier-protein] reductase (NADH).	Putative acyl-CoA thioester hydrolase.	0.418

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.735

expected number of edges:

10

PPI enrichment p-value:

0.000502

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

7 of 22

2.68

6.72

7.27e-14

GO:1902600

Proton transmembrane transport

7 of 88

2.07

4.44

6.34e-11

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

4 of 12

2.7

3.81

7.16e-08

GO:0061469

Regulation of type B pancreatic cell proliferation

2 of 9

2.52

1.33

0.0036

GO:0006796

Phosphate-containing compound metabolic process

10 of 1477

1.0

1.19

1.27e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

7 of 89

2.07

4.29

1.62e-10

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 10

2.78

3.68

1.46e-07

GO:0043027

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

2 of 10

2.48

1.19

0.0065

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

7 of 18

2.76

7.47

3.25e-15

GO:0032133

Chromosome passenger complex

4 of 7

2.93

4.35

9.43e-09

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 5

2.95

3.16

1.64e-06

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 12

2.57

2.65

1.11e-05

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 3

3.0

1.98

0.00026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22668

Mitochondrial proton-transporting ATP synthase complex

7 of 13

2.91

7.82

1.38e-15

CL:22670

CF(1), and Formation of ATP by chemiosmotic coupling

5 of 6

3.09

5.83

1.85e-11

CL:8092

Mixed, incl. Spindle midzone, and Kinesin motor, catalytic domain. ATPase.

4 of 43

2.14

2.58

6.61e-06

CL:8120

Chromosome passenger complex, and Activation of NIMA Kinases NEK9, NEK6, NEK7

3 of 12

2.57

2.43

2.92e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 166

1.86

4.18

4.21e-12

map01100

Metabolic pathways

8 of 2460

0.69

0.52

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

7 of 18

2.76

7.43

4.12e-15

MAP-8949613

Cristae formation

7 of 27

2.59

6.82

2.30e-14

MAP-1592230

Mitochondrial biogenesis

7 of 50

2.32

5.69

7.50e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

7 of 120

1.94

3.97

1.87e-10

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

7 of 178

1.77

3.26

2.17e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 40

2.05

2.27

2.44e-05

BTO:0000562

Heart

4 of 233

1.41

1.53

5.79e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

7 of 29

2.56

6.57

6.48e-14

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 11

2.73

3.81

7.47e-08

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

4 of 14

2.63

3.66

1.25e-07

GOCC:0032133

Chromosome passenger complex

3 of 4

3.05

3.13

1.97e-06

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 15

2.48

2.38

3.43e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 26

2.24

1.85

0.00029

KW-0139

CF(1)

2 of 4

2.87

1.63

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00238

Baculoviral inhibition of apoptosis protein repeat

2 of 7

2.63

1.08

0.0109

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