A0A1L9SAN5 protein (Penicilliopsis zonata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A1L9SAN5

Uncharacterized protein. (538 aa)

Predicted Functional Partners:

A0A1L9SBR1

0.729

A0A1L9SQ43

0.729

A0A1L9SA69

0.692

A0A1L9SRX4

0.692

A0A1L9SKT8

0.669

A0A1L9SKW9

0.669

A0A1L9SCA9

0.662

A0A1L9SIX8

0.662

A0A1L9SWQ3

0.662

A0A1L9STE9

0.604

Your Current Organism:

Penicilliopsis zonata

NCBI taxonomy Id: 1073090
Other names: Aspergillus zonatus CBS 506.65, P. zonata CBS 506.65, Penicilliopsis zonata CBS 506.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9SA69	A0A1L9SAN5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.692
A0A1L9SA69	A0A1L9SBR1	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.857
A0A1L9SA69	A0A1L9SCA9	Ubiquitin-like domain-containing protein.	BZIP domain-containing protein.	0.887
A0A1L9SA69	A0A1L9SIX8	Ubiquitin-like domain-containing protein.	CIA30 domain-containing protein.	0.887
A0A1L9SA69	A0A1L9SKT8	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.949
A0A1L9SA69	A0A1L9SKW9	Ubiquitin-like domain-containing protein.	RRN7-type domain-containing protein.	0.951
A0A1L9SA69	A0A1L9SQ43	Ubiquitin-like domain-containing protein.	RBR-type E3 ubiquitin transferase.	0.857
A0A1L9SA69	A0A1L9STE9	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.840
A0A1L9SA69	A0A1L9SWQ3	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.888
A0A1L9SAN5	A0A1L9SA69	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.692
A0A1L9SAN5	A0A1L9SBR1	Uncharacterized protein.	Uncharacterized protein.	0.729
A0A1L9SAN5	A0A1L9SCA9	Uncharacterized protein.	BZIP domain-containing protein.	0.662
A0A1L9SAN5	A0A1L9SIX8	Uncharacterized protein.	CIA30 domain-containing protein.	0.662
A0A1L9SAN5	A0A1L9SKT8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.669
A0A1L9SAN5	A0A1L9SKW9	Uncharacterized protein.	RRN7-type domain-containing protein.	0.669
A0A1L9SAN5	A0A1L9SQ43	Uncharacterized protein.	RBR-type E3 ubiquitin transferase.	0.729
A0A1L9SAN5	A0A1L9SRX4	Uncharacterized protein.	AN1-type domain-containing protein.	0.692
A0A1L9SAN5	A0A1L9STE9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.604
A0A1L9SAN5	A0A1L9SWQ3	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.662
A0A1L9SBR1	A0A1L9SA69	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.857

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.944

expected number of edges:

12

PPI enrichment p-value:

8.06e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000651

Positive regulation of sodium ion transmembrane transporter activity

2 of 3

2.84

0.87

0.0274

GO:1903288

Positive regulation of potassium ion import across plasma membrane

2 of 2

3.01

0.87

0.0274

GO:0010766

Negative regulation of sodium ion transport

2 of 4

2.71

0.86

0.0274

GO:0050794

Regulation of cellular process

10 of 3282

0.5

0.33

0.0274

GO:0065007

Biological regulation

11 of 4007

0.45

0.31

0.0274

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019869

Chloride channel inhibitor activity

2 of 2

3.01

1.31

0.0044

GO:0003712

Transcription coregulator activity

5 of 175

1.47

1.3

0.00070

GO:0019870

Potassium channel inhibitor activity

2 of 3

2.84

1.3

0.0044

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

5 of 30

2.24

3.45

9.69e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6417

Mediator complex

6 of 29

2.33

4.56

4.55e-10

CL:6419

Mediator complex

5 of 24

2.33

4.06

6.71e-09

CL:6429

Activator

3 of 5

2.79

2.88

4.94e-06

CL:15528

Sulfuric ester hydrolase activity, and HS-GAG degradation

2 of 19

2.04

0.91

0.0191

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-212436

Generic Transcription Pathway

6 of 695

0.95

0.56

0.0258

MAP-73857

RNA Polymerase II Transcription

6 of 805

0.89

0.52

0.0297

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

5 of 22

2.37

4.11

6.34e-09

KW-0805

Transcription regulation

5 of 119

1.64

2.05

8.47e-06

KW-0539

Nucleus

5 of 475

1.04

0.79

0.0033

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08638

Mediator complex subunit MED14

2 of 2

3.01

1.26

0.0054

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013947

Mediator complex, subunit Med14

2 of 2

3.01

0.98

0.0170

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