A0A1L9SDH9 protein (Penicilliopsis zonata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1L9SDH9

Uncharacterized protein. (287 aa)

Predicted Functional Partners:

A0A1L9SCC1

0.694

A0A1L9SHQ4

0.520

A0A1L9SID2

0.520

A0A1L9SLS4

0.485

Your Current Organism:

Penicilliopsis zonata

NCBI taxonomy Id: 1073090
Other names: Aspergillus zonatus CBS 506.65, P. zonata CBS 506.65, Penicilliopsis zonata CBS 506.65

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9SCC1	A0A1L9SDH9	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.694
A0A1L9SDH9	A0A1L9SCC1	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.694
A0A1L9SDH9	A0A1L9SHQ4	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A1L9SDH9	A0A1L9SID2	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A1L9SDH9	A0A1L9SLS4	Uncharacterized protein.	Uncharacterized protein.	0.485
A0A1L9SHQ4	A0A1L9SDH9	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A1L9SHQ4	A0A1L9SLS4	Uncharacterized protein.	Uncharacterized protein.	0.807
A0A1L9SID2	A0A1L9SDH9	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A1L9SID2	A0A1L9SLS4	Uncharacterized protein.	Uncharacterized protein.	0.807
A0A1L9SLS4	A0A1L9SDH9	Uncharacterized protein.	Uncharacterized protein.	0.485
A0A1L9SLS4	A0A1L9SHQ4	Uncharacterized protein.	Uncharacterized protein.	0.807
A0A1L9SLS4	A0A1L9SID2	Uncharacterized protein.	Uncharacterized protein.	0.807

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.651

expected number of edges:

23

PPI enrichment p-value:

0.0756

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

5 of 31

1.78

2.38

2.79e-06

GO:0007165

Signal transduction

7 of 84

1.49

2.1

6.00e-07

GO:0000160

Phosphorelay signal transduction system

6 of 71

1.5

1.97

2.79e-06

GO:0016310

Phosphorylation

6 of 116

1.29

1.44

2.44e-05

GO:0050794

Regulation of cellular process

10 of 375

1.0

1.14

6.00e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 33

1.96

4.46

5.50e-12

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 172

1.29

1.96

2.67e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

10 of 904

0.62

0.52

0.00030

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3388

Mixed, incl. Nucleotide cyclase, and MHYT domain

5 of 10

2.27

3.79

1.92e-08

CL:3391

MHYT domain, and PAC motif

4 of 5

2.48

3.41

2.79e-07

CL:3496

Two-component regulatory system, and His Kinase A (phosphoacceptor) domain

6 of 30

1.87

3.22

1.92e-08

CL:3294

Cilium, and Signal transduction

11 of 146

1.45

2.87

1.56e-13

CL:3501

Two-component regulatory system, and His Kinase A (phosphoacceptor) domain

3 of 16

1.85

1.53

0.00070

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

8 of 285

1.02

1.09

1.00e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 98

1.43

2.0

3.87e-07

KW-0902

Two-component regulatory system

4 of 26

1.76

1.85

8.11e-05

KW-0597

Phosphoprotein

3 of 46

1.39

0.9

0.0090

KW-0067

ATP-binding

6 of 303

0.87

0.66

0.0032

KW-0175

Coiled coil

5 of 281

0.82

0.53

0.0162

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03707

Bacterial signalling protein N terminal repeat

2 of 2

2.57

0.9

0.0236

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 23

2.06

4.18

2.76e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 24

2.04

4.14

2.76e-10

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 28

1.97

3.98

3.02e-10

IPR005467

Histidine kinase domain

7 of 30

1.94

3.89

3.47e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 35

1.87

3.64

7.24e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 23

2.06

4.54

2.41e-11

SM00387

Histidine kinase-like ATPases

7 of 34

1.89

3.88

1.32e-10

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 16

2.07

3.4

4.53e-08

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 15

2.0

2.61

3.04e-06

SM00091

PAS domain

5 of 34

1.74

2.47

9.41e-07

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About