A0A1L9SRH7 protein (Penicilliopsis zonata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1L9SRH7

Uncharacterized protein. (151 aa)

Predicted Functional Partners:

A0A1L9S9B2

0.998

A0A1L9S991

0.996

A0A1L9SD57

0.988

A0A1L9SNZ3

0.971

A0A1L9SGX5

0.935

A0A1L9SJ94

0.887

A0A1L9SRH6

0.880

A0A1L9S6M5

0.847

A0A1L9SP23

0.833

A0A1L9SIC2

0.829

Your Current Organism:

Penicilliopsis zonata

NCBI taxonomy Id: 1073090
Other names: Aspergillus zonatus CBS 506.65, P. zonata CBS 506.65, Penicilliopsis zonata CBS 506.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9S6M5	A0A1L9S991	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.753
A0A1L9S6M5	A0A1L9S9B2	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.780
A0A1L9S6M5	A0A1L9SD57	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.681
A0A1L9S6M5	A0A1L9SGX5	zf-Tim10_DDP domain-containing protein.	Bac_surface_Ag domain-containing protein.	0.497
A0A1L9S6M5	A0A1L9SJ94	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.898
A0A1L9S6M5	A0A1L9SNZ3	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.523
A0A1L9S6M5	A0A1L9SP23	zf-Tim10_DDP domain-containing protein.	zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family.	0.920
A0A1L9S6M5	A0A1L9SRH7	zf-Tim10_DDP domain-containing protein.	Uncharacterized protein.	0.847
A0A1L9S991	A0A1L9S6M5	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.753
A0A1L9S991	A0A1L9S9B2	Uncharacterized protein.	Uncharacterized protein.	0.989
A0A1L9S991	A0A1L9SD57	Uncharacterized protein.	Uncharacterized protein.	0.984
A0A1L9S991	A0A1L9SGX5	Uncharacterized protein.	Bac_surface_Ag domain-containing protein.	0.980
A0A1L9S991	A0A1L9SIC2	Uncharacterized protein.	Uncharacterized protein.	0.973
A0A1L9S991	A0A1L9SJ94	Uncharacterized protein.	Uncharacterized protein.	0.847
A0A1L9S991	A0A1L9SNZ3	Uncharacterized protein.	Uncharacterized protein.	0.968
A0A1L9S991	A0A1L9SP23	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family.	0.738
A0A1L9S991	A0A1L9SRH6	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.558
A0A1L9S991	A0A1L9SRH7	Uncharacterized protein.	Uncharacterized protein.	0.996
A0A1L9S9B2	A0A1L9S6M5	Uncharacterized protein.	zf-Tim10_DDP domain-containing protein.	0.780
A0A1L9S9B2	A0A1L9S991	Uncharacterized protein.	Uncharacterized protein.	0.989

page 1 of 5

Network Stats

number of nodes:

9

number of edges:

8

average node degree:

1.78

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

0.602

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035385

Roundabout signaling pathway

3 of 4

3.15

2.96

4.27e-06

GO:0070100

Negative regulation of chemokine-mediated signaling pathway

3 of 6

2.97

2.81

7.51e-06

GO:0050919

Negative chemotaxis

4 of 37

2.31

2.75

4.36e-06

GO:0022028

Tangential migration from the subventricular zone to the olfactory bulb

3 of 8

2.85

2.68

1.23e-05

GO:0048846

Axon extension involved in axon guidance

3 of 10

2.75

2.6

1.60e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048495

Roundabout binding

3 of 7

2.9

2.39

4.30e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:19737524

(2009) The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.

4 of 18

2.62

2.09

0.00014

PMID:29907785

(2018) Inhibitory effect of SLIT2 on granulosa cell proliferation mediated by the CDC42-PAKs-ERK12 MAPK pathway in the prehierarchical follicles of the chicken ovary.

4 of 20

2.57

2.08

0.00014

PMID:32678266

(2020) Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation.

3 of 8

2.85

1.41

0.0028

PMID:27923383

(2016) srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.

3 of 9

2.8

1.41

0.0028

PMID:30906431

(2019) Antagonistic effects of exogenous Slit2 on VEGF-induced choroidal endothelial cell migration and tube formation.

3 of 11

2.71

1.4

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17851

Regulation of commissural axon pathfinding by SLIT and ROBO, and Roundabout signaling pathway

8 of 11

3.13

10.23

6.74e-20

CL:17853

Roundabout signaling pathway, and Regulation of commissural axon pathfinding by SLIT and ROBO

4 of 6

3.1

4.47

6.69e-09

CL:20575

Cytoplasmic protein NCK, and p21 activated kinase binding domain

2 of 5

2.87

1.36

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ocu04360

Axon guidance

9 of 142

2.07

5.94

8.62e-16

ocu04012

ErbB signaling pathway

3 of 64

1.94

1.53

0.00088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-376176

Signaling by ROBO receptors

5 of 25

2.57

4.39

3.59e-09

MAP-9010553

Regulation of expression of SLITs and ROBOs

4 of 15

2.7

3.65

1.44e-07

MAP-422475

Axon guidance

7 of 385

1.53

2.3

1.50e-07

MAP-9675108

Nervous system development

7 of 402

1.51

2.26

1.51e-07

MAP-8985586

SLIT2:ROBO1 increases RHOA activity

2 of 3

3.1

1.83

0.00049

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

4 of 173

1.64

1.43

0.00068

KW-0433

Leucine-rich repeat

3 of 104

1.73

1.15

0.0045

KW-0343

GTPase activation

2 of 48

1.89

0.83

0.0256

KW-0245

EGF-like domain

3 of 195

1.46

0.81

0.0186

KW-0677

Repeat

5 of 1117

0.92

0.58

0.0186

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR031160

F-BAR domain

3 of 18

2.49

1.62

0.0010

IPR013032

EGF-like, conserved site

3 of 20

2.45

1.62

0.0010

IPR006207

Cystine knot, C-terminal

3 of 19

2.47

1.62

0.0010

IPR035648

srGAP1/2/3, SH3 domain

2 of 2

3.27

1.48

0.0022

IPR000372

Leucine-rich repeat N-terminal domain

3 of 39

2.16

1.4

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00041

C-terminal cystine knot-like domain (CTCK)

3 of 17

2.52

2.15

0.00010

SM00282

Laminin G domain

3 of 37

2.18

1.75

0.00044

SM00274

Follistatin-N-terminal domain-like

2 of 7

2.73

1.57

0.0014

SM00326

Src homology 3 domains

4 of 174

1.63

1.49

0.00045

SM00082

Leucine rich repeat C-terminal domain

3 of 68

1.92

1.45

0.0013

(more ...)

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