A0A1L9SS60 protein (Penicilliopsis zonata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A1L9SS60

Brix domain-containing protein. (302 aa)

Predicted Functional Partners:

A0A1L9SQS6

0.999

A0A1L9STR9

0.999

A0A1L9S858

0.998

A0A1L9SIM6

0.998

A0A1L9SEJ0

0.997

A0A1L9S824

0.996

A0A1L9SA44

0.996

A0A1L9SC16

0.996

A0A1L9SC20

0.996

A0A1L9SED3

0.996

Your Current Organism:

Penicilliopsis zonata

NCBI taxonomy Id: 1073090
Other names: Aspergillus zonatus CBS 506.65, P. zonata CBS 506.65, Penicilliopsis zonata CBS 506.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9S824	A0A1L9S858	WD_REPEATS_REGION domain-containing protein.	U3 small nucleolar RNA-associated protein 22.	0.998
A0A1L9S824	A0A1L9SA44	WD_REPEATS_REGION domain-containing protein.	Utp12 domain-containing protein.	0.999
A0A1L9S824	A0A1L9SC16	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.996
A0A1L9S824	A0A1L9SC20	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.999
A0A1L9S824	A0A1L9SED3	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.999
A0A1L9S824	A0A1L9SEJ0	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.998
A0A1L9S824	A0A1L9SIM6	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.999
A0A1L9S824	A0A1L9SQS6	WD_REPEATS_REGION domain-containing protein.	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.	0.998
A0A1L9S824	A0A1L9SS60	WD_REPEATS_REGION domain-containing protein.	Brix domain-containing protein.	0.996
A0A1L9S824	A0A1L9STR9	WD_REPEATS_REGION domain-containing protein.	S4 RNA-binding domain-containing protein.	0.995
A0A1L9S858	A0A1L9S824	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.998
A0A1L9S858	A0A1L9SA44	U3 small nucleolar RNA-associated protein 22.	Utp12 domain-containing protein.	0.998
A0A1L9S858	A0A1L9SC16	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.998
A0A1L9S858	A0A1L9SC20	U3 small nucleolar RNA-associated protein 22.	Uncharacterized protein.	0.999
A0A1L9S858	A0A1L9SED3	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.999
A0A1L9S858	A0A1L9SEJ0	U3 small nucleolar RNA-associated protein 22.	Uncharacterized protein.	0.997
A0A1L9S858	A0A1L9SIM6	U3 small nucleolar RNA-associated protein 22.	WD_REPEATS_REGION domain-containing protein.	0.999
A0A1L9S858	A0A1L9SQS6	U3 small nucleolar RNA-associated protein 22.	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.	0.998
A0A1L9S858	A0A1L9SS60	U3 small nucleolar RNA-associated protein 22.	Brix domain-containing protein.	0.998
A0A1L9S858	A0A1L9STR9	U3 small nucleolar RNA-associated protein 22.	S4 RNA-binding domain-containing protein.	0.993

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.831

expected number of edges:

12

PPI enrichment p-value:

2.24e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000151

Ubiquitin ligase complex

5 of 307

1.43

1.21

0.0011

GO:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.74

1.16

0.0080

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18698375

(2008) Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping.

3 of 13

2.58

1.36

0.0032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3248

COMM domain, and SOCS box-like domain superfamily

5 of 31

2.42

3.78

4.13e-08

CL:3253

COMM domain

3 of 11

2.65

2.38

3.91e-05

CL:3255

COMM domain

2 of 5

2.82

1.36

0.0034

CL:3284

SOCS box-like domain superfamily

2 of 6

2.74

1.32

0.0040

CL:10434

cullin-RING ubiquitin ligase complex, and Protein neddylation

3 of 87

1.75

1.06

0.0074

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05170

Human immunodeficiency virus 1 infection

4 of 221

1.47

1.13

0.0025

map04120

Ubiquitin mediated proteolysis

4 of 279

1.37

1.04

0.0031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

10 of 335

1.69

3.88

1.02e-13

MAP-9705462

Inactivation of CSF3 (G-CSF) signaling

4 of 26

2.4

3.08

1.14e-06

MAP-9674555

Signaling by CSF3 (G-CSF)

4 of 30

2.34

3.0

1.44e-06

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

6 of 422

1.37

1.58

2.00e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

6 of 482

1.31

1.45

3.73e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031466

Cul5-RING ubiquitin ligase complex

3 of 7

2.85

2.58

1.91e-05

GOCC:0000151

Ubiquitin ligase complex

6 of 250

1.6

2.03

6.28e-06

GOCC:0070449

Elongin complex

2 of 4

2.92

1.5

0.0019

GOCC:0031461

cullin-RING ubiquitin ligase complex

4 of 152

1.64

1.35

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

3 of 10

2.69

2.17

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

3 of 10

2.69

1.91

0.00032

IPR047155

COMM domain-containing protein 4/6/7/8

2 of 4

2.92

0.98

0.0169

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