A0A1L9SWI1 protein (Penicilliopsis zonata) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A1L9SWI1

Uncharacterized protein. (358 aa)

Predicted Functional Partners:

A0A1L9SPV4

0.976

A0A1L9SP25

0.949

A0A1L9SPE6

0.949

A0A1L9SFM2

0.925

A0A1L9SA24

0.917

A0A1L9STN2

0.917

A0A1L9SIT6

0.905

A0A1L9SW03

0.898

A0A1L9SIF8

0.897

A0A1L9SD77

0.885

Your Current Organism:

Penicilliopsis zonata

NCBI taxonomy Id: 1073090
Other names: Aspergillus zonatus CBS 506.65, P. zonata CBS 506.65, Penicilliopsis zonata CBS 506.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9SA24	A0A1L9SD77	Uncharacterized protein.	RRM domain-containing protein.	0.565
A0A1L9SA24	A0A1L9SP25	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.480
A0A1L9SA24	A0A1L9SW03	Uncharacterized protein.	RRM domain-containing protein.	0.819
A0A1L9SA24	A0A1L9SWI1	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A1L9SD77	A0A1L9SA24	RRM domain-containing protein.	Uncharacterized protein.	0.565
A0A1L9SD77	A0A1L9SFM2	RRM domain-containing protein.	Uncharacterized protein.	0.711
A0A1L9SD77	A0A1L9SIF8	RRM domain-containing protein.	Pinin_SDK_memA domain-containing protein.	0.805
A0A1L9SD77	A0A1L9SIT6	RRM domain-containing protein.	Uncharacterized protein.	0.999
A0A1L9SD77	A0A1L9SP25	RRM domain-containing protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.978
A0A1L9SD77	A0A1L9SPE6	RRM domain-containing protein.	SAP domain-containing protein.	0.680
A0A1L9SD77	A0A1L9SPV4	RRM domain-containing protein.	RanBD1 domain-containing protein.	0.977
A0A1L9SD77	A0A1L9STN2	RRM domain-containing protein.	RRM domain-containing protein.	0.565
A0A1L9SD77	A0A1L9SW03	RRM domain-containing protein.	RRM domain-containing protein.	0.977
A0A1L9SD77	A0A1L9SWI1	RRM domain-containing protein.	Uncharacterized protein.	0.885
A0A1L9SFM2	A0A1L9SD77	Uncharacterized protein.	RRM domain-containing protein.	0.711
A0A1L9SFM2	A0A1L9SIF8	Uncharacterized protein.	Pinin_SDK_memA domain-containing protein.	0.994
A0A1L9SFM2	A0A1L9SP25	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.905
A0A1L9SFM2	A0A1L9SPE6	Uncharacterized protein.	SAP domain-containing protein.	0.998
A0A1L9SFM2	A0A1L9SW03	Uncharacterized protein.	RRM domain-containing protein.	0.897
A0A1L9SFM2	A0A1L9SWI1	Uncharacterized protein.	Uncharacterized protein.	0.925

page 1 of 4

Network Stats

number of nodes:

6

number of edges:

7

average node degree:

2.33

avg. local clustering coefficient:

0.867

expected number of edges:

5

PPI enrichment p-value:

0.24

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006526

Arginine biosynthetic process

9 of 11

2.9

10.4

6.58e-21

GO:0006591

Ornithine metabolic process

4 of 9

2.64

3.7

1.04e-07

GO:0042450

Arginine biosynthetic process via ornithine

3 of 3

2.99

3.01

3.26e-06

GO:0019752

Carboxylic acid metabolic process

10 of 651

1.17

1.66

2.58e-09

GO:1901564

Organonitrogen compound metabolic process

10 of 2158

0.65

0.56

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.99

1.13

0.0091

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 3

2.81

1.13

0.0091

GO:0004056

Argininosuccinate lyase activity

2 of 2

2.99

1.13

0.0091

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.99

1.13

0.0091

GO:0003824

Catalytic activity

11 of 4783

0.35

0.26

0.0379

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005759

Mitochondrial matrix

4 of 191

1.31

0.7

0.0266

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13059

Arginine metabolic process, and ArgE/DapE/ACY1/CPG2/YscS, conserved site

8 of 17

2.66

8.05

8.11e-17

CL:13062

Arginine biosynthetic process, and Homoserine biosynthetic process

7 of 10

2.83

7.81

9.91e-16

CL:12986

Mixed, incl. Arginine biosynthesis, and Carbon-nitrogen hydrolase

9 of 67

2.12

6.08

9.91e-16

CL:13064

Arginine biosynthesis, and Argininosuccinate lyase

4 of 5

2.89

4.18

1.85e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00220

Arginine biosynthesis

9 of 40

2.34

7.73

3.32e-18

map00250

Alanine, aspartate and glutamate metabolism

5 of 62

1.89

2.97

1.39e-07

map01230

Biosynthesis of amino acids

9 of 263

1.52

2.92

1.53e-11

map01210

2-Oxocarboxylic acid metabolism

5 of 71

1.84

2.82

2.12e-07

map01110

Biosynthesis of secondary metabolites

10 of 1029

0.98

1.16

3.57e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70635

Urea cycle

6 of 17

2.54

5.41

2.09e-11

MAP-71291

Metabolism of amino acids and derivatives

6 of 374

1.19

1.12

0.00036

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

2 of 2

2.99

1.58

0.0014

KW-0028

Amino-acid biosynthesis

3 of 34

1.93

1.44

0.0014

KW-0511

Multifunctional enzyme

2 of 19

2.01

1.01

0.0120

KW-0496

Mitochondrion

3 of 99

1.47

0.91

0.0105

KW-0456

Lyase

3 of 118

1.39

0.85

0.0120

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14698

Argininosuccinate lyase C-terminal

2 of 2

2.99

1.23

0.0061

PF04768

NAT, N-acetyltransferase, of N-acetylglutamate synthase

2 of 2

2.99

1.23

0.0061

PF00206

Lyase

2 of 5

2.59

1.18

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029419

Argininosuccinate lyase, C-terminal

2 of 2

2.99

0.98

0.0169

IPR024083

Fumarase/histidase, N-terminal

2 of 3

2.81

0.98

0.0169

IPR009049

Argininosuccinate lyase

2 of 2

2.99

0.98

0.0169

IPR006855

Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain

2 of 2

2.99

0.98

0.0169

IPR022761

Fumarate lyase, N-terminal

2 of 5

2.59

0.97

0.0169

(more ...)

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