SFF65148.1 protein (Fontimonas thermophila) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

SFF65148.1

TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase. (166 aa)

Predicted Functional Partners:

SFF65141.1

0.980

SFF65128.1

0.929

SFF65162.1

0.651

pgk

0.477

Your Current Organism:

Fontimonas thermophila

NCBI taxonomy Id: 1076937
Other names: CCUG 59713, DSM 23609, F. thermophila, Fontimonas thermophila Losey et al. 2013, Solimonas sp. HA-01, strain HA-01

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFF65128.1	SFF65141.1	SAMN04488120_11730	SAMN04488120_11731	LemA protein.	Uncharacterized protein.	0.948
SFF65128.1	SFF65148.1	SAMN04488120_11730	SAMN04488120_11732	LemA protein.	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	0.929
SFF65128.1	SFF65162.1	SAMN04488120_11730	SAMN04488120_11733	LemA protein.	MoxR-like ATPase.	0.626
SFF65128.1	pgk	SAMN04488120_11730	SAMN04488120_11729	LemA protein.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.493
SFF65141.1	SFF65128.1	SAMN04488120_11731	SAMN04488120_11730	Uncharacterized protein.	LemA protein.	0.948
SFF65141.1	SFF65148.1	SAMN04488120_11731	SAMN04488120_11732	Uncharacterized protein.	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	0.980
SFF65141.1	SFF65162.1	SAMN04488120_11731	SAMN04488120_11733	Uncharacterized protein.	MoxR-like ATPase.	0.651
SFF65141.1	pgk	SAMN04488120_11731	SAMN04488120_11729	Uncharacterized protein.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.476
SFF65148.1	SFF65128.1	SAMN04488120_11732	SAMN04488120_11730	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	LemA protein.	0.929
SFF65148.1	SFF65141.1	SAMN04488120_11732	SAMN04488120_11731	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	Uncharacterized protein.	0.980
SFF65148.1	SFF65162.1	SAMN04488120_11732	SAMN04488120_11733	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	MoxR-like ATPase.	0.651
SFF65148.1	pgk	SAMN04488120_11732	SAMN04488120_11729	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.477
SFF65162.1	SFF65128.1	SAMN04488120_11733	SAMN04488120_11730	MoxR-like ATPase.	LemA protein.	0.626
SFF65162.1	SFF65141.1	SAMN04488120_11733	SAMN04488120_11731	MoxR-like ATPase.	Uncharacterized protein.	0.651
SFF65162.1	SFF65148.1	SAMN04488120_11733	SAMN04488120_11732	MoxR-like ATPase.	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	0.651
SFF65162.1	pgk	SAMN04488120_11733	SAMN04488120_11729	MoxR-like ATPase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.409
pgk	SFF65128.1	SAMN04488120_11729	SAMN04488120_11730	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	LemA protein.	0.493
pgk	SFF65141.1	SAMN04488120_11729	SAMN04488120_11731	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	Uncharacterized protein.	0.476
pgk	SFF65148.1	SAMN04488120_11729	SAMN04488120_11732	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	TLP18.3, Psb32 and MOLO-1 founding protein of phosphatase.	0.477
pgk	SFF65162.1	SAMN04488120_11729	SAMN04488120_11733	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	MoxR-like ATPase.	0.409

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051123

RNA polymerase II preinitiation complex assembly

8 of 18

2.92

9.32

1.35e-18

GO:0006367

Transcription initiation from RNA polymerase II promoter

9 of 34

2.7

9.28

2.13e-19

GO:0006352

DNA-templated transcription, initiation

10 of 81

2.36

8.24

2.13e-19

GO:0042789

mRNA transcription by RNA polymerase II

8 of 41

2.56

7.65

2.33e-16

GO:0060261

Positive regulation of transcription initiation from RNA polymerase II promoter

8 of 46

2.51

7.42

4.48e-16

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016251

RNA polymerase II general transcription initiation factor activity

5 of 25

2.57

4.39

3.55e-09

GO:0140296

General transcription initiation factor binding

5 of 54

2.24

3.54

6.18e-08

GO:0017025

TBP-class protein binding

4 of 28

2.43

3.15

8.77e-07

GO:0046982

Protein heterodimerization activity

8 of 334

1.65

2.94

2.81e-09

GO:0008134

Transcription factor binding

8 of 636

1.37

1.99

8.87e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

10 of 29

2.81

11.72

3.14e-24

GO:0033276

Transcription factor TFTC complex

6 of 14

2.9

7.14

3.19e-14

GO:0070461

SAGA-type complex

7 of 37

2.55

6.95

8.57e-15

GO:0000124

SAGA complex

4 of 23

2.51

3.73

6.89e-08

GO:0071339

MLL1 complex

4 of 34

2.34

3.35

2.61e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4168

RNA polymerase II preinitiation complex assembly

9 of 10

3.23

12.24

1.25e-23

CL:4125

Transcription factor TFIID complex, and Transcription factor TFIIH holo complex

10 of 34

2.74

11.2

1.63e-23

CL:4172

SLIK (SAGA-like) complex, and Lateral mesoderm formation

5 of 5

3.27

6.35

2.44e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03022

Basal transcription factors

9 of 34

2.7

9.97

5.56e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

9 of 49

2.54

8.68

5.40e-19

MAP-75953

RNA Polymerase II Transcription Initiation

9 of 49

2.54

8.68

5.40e-19

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

9 of 49

2.54

8.68

5.40e-19

MAP-73776

RNA Polymerase II Promoter Escape

9 of 49

2.54

8.68

5.40e-19

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 101

2.22

6.9

4.69e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016591

RNA polymerase II, holoenzyme

10 of 64

2.47

9.27

4.03e-21

GOCC:0070461

SAGA-type complex

7 of 34

2.59

7.03

7.63e-15

GOCC:0071339

MLL1 complex

4 of 26

2.46

3.55

1.37e-07

GOCC:0005654

Nucleoplasm

11 of 696

1.47

3.04

1.99e-14

GOCC:1990234

Transferase complex

11 of 858

1.38

2.6

1.71e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

4 of 59

2.1

2.46

1.07e-05

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