node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | BUAP5A_102 | BUAP5A_100 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | BUAP5A_102 | BUAP5A_099 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
hisA | hisD | BUAP5A_102 | BUAP5A_098 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | BUAP5A_102 | BUAP5A_103 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | BUAP5A_102 | BUAP5A_097 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.996 |
hisA | hisH | BUAP5A_102 | BUAP5A_101 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Amidotransferase hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | BUAP5A_102 | BUAP5A_104 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | pheA | BUAP5A_102 | BUAP5A_385 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.763 |
hisA | trpC | BUAP5A_102 | BUAP5A_274 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.884 |
hisB | hisA | BUAP5A_100 | BUAP5A_102 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.999 |
hisB | hisC | BUAP5A_100 | BUAP5A_099 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BUAP5A_100 | BUAP5A_098 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | BUAP5A_100 | BUAP5A_103 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | BUAP5A_100 | BUAP5A_097 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.999 |
hisB | hisH | BUAP5A_100 | BUAP5A_101 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Amidotransferase hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisI | BUAP5A_100 | BUAP5A_104 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB | lpcA | BUAP5A_100 | BUAP5A_245 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | 0.918 |
hisB | pheA | BUAP5A_100 | BUAP5A_385 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.951 |
hisB | trpC | BUAP5A_100 | BUAP5A_274 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Histidinol-phosphate phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.926 |
hisC | hisA | BUAP5A_099 | BUAP5A_102 | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.996 |