node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | BUAP5A_143 | BUAP5A_142 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | Carbamoyl-phosphate synthase large subunit. | 0.999 |
carA | folA | BUAP5A_143 | BUAP5A_141 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.552 |
carA | purH | BUAP5A_143 | BUAP5A_030 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | IMP cyclohydrolase. | 0.584 |
carA | thrA | BUAP5A_143 | BUAP5A_191 | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | Bifunctional aspartokinase I/homeserine dehydrogenase I; Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.554 |
carB | carA | BUAP5A_142 | BUAP5A_143 | Carbamoyl-phosphate synthase large subunit. | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | 0.999 |
carB | clpX | BUAP5A_142 | BUAP5A_469 | Carbamoyl-phosphate synthase large subunit. | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.523 |
carB | folA | BUAP5A_142 | BUAP5A_141 | Carbamoyl-phosphate synthase large subunit. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.567 |
carB | glyA | BUAP5A_142 | BUAP5A_284 | Carbamoyl-phosphate synthase large subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.472 |
carB | purH | BUAP5A_142 | BUAP5A_030 | Carbamoyl-phosphate synthase large subunit. | IMP cyclohydrolase. | 0.529 |
carB | thrA | BUAP5A_142 | BUAP5A_191 | Carbamoyl-phosphate synthase large subunit. | Bifunctional aspartokinase I/homeserine dehydrogenase I; Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.503 |
clpX | carB | BUAP5A_469 | BUAP5A_142 | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Carbamoyl-phosphate synthase large subunit. | 0.523 |
clpX | folA | BUAP5A_469 | BUAP5A_141 | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.527 |
clpX | pheA | BUAP5A_469 | BUAP5A_385 | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.416 |
clpX | thrA | BUAP5A_469 | BUAP5A_191 | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Bifunctional aspartokinase I/homeserine dehydrogenase I; Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.523 |
fmt | folA | BUAP5A_490 | BUAP5A_141 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.946 |
fmt | folC | BUAP5A_490 | BUAP5A_165 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.461 |
fmt | glyA | BUAP5A_490 | BUAP5A_284 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
fmt | purH | BUAP5A_490 | BUAP5A_030 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | IMP cyclohydrolase. | 0.461 |
fmt | thyA | BUAP5A_490 | BUAP5A_433 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.622 |
folA | carA | BUAP5A_141 | BUAP5A_143 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. | 0.552 |