node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argA | mfd | BUAP5A_449 | BUAP5A_289 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity); In the N-terminal section; belongs to the UvrB family. | 0.474 |
argA | murI | BUAP5A_449 | BUAP5A_547 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.418 |
argA | mutY | BUAP5A_449 | BUAP5A_545 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | 0.495 |
argA | trpC | BUAP5A_449 | BUAP5A_274 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.875 |
argA | yggX | BUAP5A_449 | BUAP5A_546 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | Protein that protects iron-sulfur proteins against oxidative damage (YggX); Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.447 |
argA | yqgF | BUAP5A_449 | BUAP5A_541 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | Predicted Holliday junction resolvase (YqgF); Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | 0.412 |
dnaN | mutY | BUAP5A_011 | BUAP5A_545 | DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | 0.721 |
mfd | argA | BUAP5A_289 | BUAP5A_449 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity); In the N-terminal section; belongs to the UvrB family. | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.474 |
mfd | mutY | BUAP5A_289 | BUAP5A_545 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity); In the N-terminal section; belongs to the UvrB family. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | 0.473 |
mfd | nth | BUAP5A_289 | BUAP5A_117 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity); In the N-terminal section; belongs to the UvrB family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.510 |
murI | argA | BUAP5A_547 | BUAP5A_449 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.418 |
murI | mutY | BUAP5A_547 | BUAP5A_545 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | 0.533 |
murI | yggH | BUAP5A_547 | BUAP5A_544 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.405 |
murI | yggX | BUAP5A_547 | BUAP5A_546 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Protein that protects iron-sulfur proteins against oxidative damage (YggX); Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.533 |
mutY | argA | BUAP5A_545 | BUAP5A_449 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.495 |
mutY | dnaN | BUAP5A_545 | BUAP5A_011 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.721 |
mutY | mfd | BUAP5A_545 | BUAP5A_289 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity); In the N-terminal section; belongs to the UvrB family. | 0.473 |
mutY | murI | BUAP5A_545 | BUAP5A_547 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.533 |
mutY | nfo | BUAP5A_545 | BUAP5A_135 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. | 0.501 |
mutY | nth | BUAP5A_545 | BUAP5A_117 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.529 |