node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gyrA | lepB | BUAP5A_177 | BUAP5A_254 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | 0.776 |
gyrA | lolD | BUAP5A_177 | BUAP5A_291 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.479 |
gyrA | lspA | BUAP5A_177 | BUAP5A_146 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.474 |
gyrA | rpoC | BUAP5A_177 | BUAP5A_032 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.495 |
gyrA | valS | BUAP5A_177 | BUAP5A_359 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.515 |
gyrA | yajR | BUAP5A_177 | BUAP5A_459 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Hypothetical protein. | 0.461 |
ksgA | lolD | BUAP5A_139 | BUAP5A_291 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.678 |
ksgA | valS | BUAP5A_139 | BUAP5A_359 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.463 |
ksgA | ygjD | BUAP5A_139 | BUAP5A_057 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.640 |
lepB | gyrA | BUAP5A_254 | BUAP5A_177 | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.776 |
lepB | lolC | BUAP5A_254 | BUAP5A_290 | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | LolCDE ABC lipoprotein transporter (YcfU); Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. | 0.606 |
lepB | lolD | BUAP5A_254 | BUAP5A_291 | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.507 |
lepB | lspA | BUAP5A_254 | BUAP5A_146 | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.770 |
lepB | yidC | BUAP5A_254 | BUAP5A_015 | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | 60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.713 |
lolC | lepB | BUAP5A_290 | BUAP5A_254 | LolCDE ABC lipoprotein transporter (YcfU); Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. | Signal peptidase I. Serine peptidase. MEROPS family S26A; Belongs to the peptidase S26 family. | 0.606 |
lolC | lolD | BUAP5A_290 | BUAP5A_291 | LolCDE ABC lipoprotein transporter (YcfU); Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | 0.999 |
lolC | lspA | BUAP5A_290 | BUAP5A_146 | LolCDE ABC lipoprotein transporter (YcfU); Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.527 |
lolC | yidC | BUAP5A_290 | BUAP5A_015 | LolCDE ABC lipoprotein transporter (YcfU); Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. | 60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.558 |
lolD | gyrA | BUAP5A_291 | BUAP5A_177 | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.479 |
lolD | ksgA | BUAP5A_291 | BUAP5A_139 | LolCDE ABC lipoprotein transporter (YcfV); Usually LolD forms an ABC transporter complex with LolC and LolE involved in the translocation of lipoprotein, in an ATP-dependent manner. However, LolE is certainly not functional as it is frameshifted; Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.678 |