| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BVIR_1304 | queD | BVIR_1304 | BVIR_1306 | Exopolysaccharide synthesis, ExoD. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.510 |
| BVIR_1304 | queE | BVIR_1304 | BVIR_1305 | Exopolysaccharide synthesis, ExoD. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.525 |
| BVIR_2109 | nrdD | BVIR_2109 | BVIR_2110 | Hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase. | 0.945 |
| BVIR_2109 | queE | BVIR_2109 | BVIR_1305 | Hypothetical protein. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.840 |
| folE_1 | nrdD | BVIR_1779 | BVIR_2110 | GTP cyclohydrolase 1. | Anaerobic ribonucleoside-triphosphate reductase. | 0.800 |
| folE_1 | queC | BVIR_1779 | BVIR_1428 | GTP cyclohydrolase 1. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.490 |
| folE_1 | queD | BVIR_1779 | BVIR_1306 | GTP cyclohydrolase 1. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.989 |
| folE_1 | queE | BVIR_1779 | BVIR_1305 | GTP cyclohydrolase 1. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.628 |
| folE_1 | queF | BVIR_1779 | BVIR_1931 | GTP cyclohydrolase 1. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.490 |
| guaA_2 | queD | BVIR_227 | BVIR_1306 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.521 |
| guaA_2 | queE | BVIR_227 | BVIR_1305 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.539 |
| guaA_2 | queF | BVIR_227 | BVIR_1931 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.540 |
| guaA_2 | tgt | BVIR_227 | BVIR_1939 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.677 |
| nrdD | BVIR_2109 | BVIR_2110 | BVIR_2109 | Anaerobic ribonucleoside-triphosphate reductase. | Hypothetical protein. | 0.945 |
| nrdD | folE_1 | BVIR_2110 | BVIR_1779 | Anaerobic ribonucleoside-triphosphate reductase. | GTP cyclohydrolase 1. | 0.800 |
| nrdD | queE | BVIR_2110 | BVIR_1305 | Anaerobic ribonucleoside-triphosphate reductase. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.940 |
| queC | folE_1 | BVIR_1428 | BVIR_1779 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | GTP cyclohydrolase 1. | 0.490 |
| queC | queD | BVIR_1428 | BVIR_1306 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.957 |
| queC | queE | BVIR_1428 | BVIR_1305 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.994 |
| queC | queF | BVIR_1428 | BVIR_1931 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.991 |