| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BVIR_132 | BVIR_133 | BVIR_132 | BVIR_133 | Putative protoheme IX biogenesis protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.887 |
| BVIR_132 | gcp | BVIR_132 | BVIR_135 | Putative protoheme IX biogenesis protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.662 |
| BVIR_132 | hemC | BVIR_132 | BVIR_134 | Putative protoheme IX biogenesis protein. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.782 |
| BVIR_133 | BVIR_132 | BVIR_133 | BVIR_132 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Putative protoheme IX biogenesis protein. | 0.887 |
| BVIR_133 | cysG_2 | BVIR_133 | BVIR_2058 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase. | 0.613 |
| BVIR_133 | gcp | BVIR_133 | BVIR_135 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | tRNA N6-adenosine threonylcarbamoyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.712 |
| BVIR_133 | hemB | BVIR_133 | BVIR_831 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.889 |
| BVIR_133 | hemC | BVIR_133 | BVIR_134 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
| BVIR_133 | hemE | BVIR_133 | BVIR_3288 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.746 |
| BVIR_133 | hemH | BVIR_133 | BVIR_713 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.536 |
| BVIR_133 | hemL_1 | BVIR_133 | BVIR_346 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Beta-phenylalanine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.542 |
| cysG_1 | cysG_2 | BVIR_1702 | BVIR_2058 | Siroheme synthase; Belongs to the precorrin methyltransferase family. | Siroheme synthase. | 0.969 |
| cysG_1 | hemB | BVIR_1702 | BVIR_831 | Siroheme synthase; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.880 |
| cysG_1 | hemC | BVIR_1702 | BVIR_134 | Siroheme synthase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.988 |
| cysG_1 | hemE | BVIR_1702 | BVIR_3288 | Siroheme synthase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.918 |
| cysG_1 | hemL_1 | BVIR_1702 | BVIR_346 | Siroheme synthase; Belongs to the precorrin methyltransferase family. | Beta-phenylalanine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.675 |
| cysG_2 | BVIR_133 | BVIR_2058 | BVIR_133 | Siroheme synthase. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.613 |
| cysG_2 | cysG_1 | BVIR_2058 | BVIR_1702 | Siroheme synthase. | Siroheme synthase; Belongs to the precorrin methyltransferase family. | 0.969 |
| cysG_2 | hemB | BVIR_2058 | BVIR_831 | Siroheme synthase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.850 |
| cysG_2 | hemC | BVIR_2058 | BVIR_134 | Siroheme synthase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.900 |