| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folB | folE_1 | BVIR_2636 | BVIR_1779 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase 1. | 0.965 |
| folB | folP_1 | BVIR_2636 | BVIR_2635 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| folB | ftsH_1 | BVIR_2636 | BVIR_2739 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.561 |
| folB | ribBA_1 | BVIR_2636 | BVIR_1959 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.468 |
| folB | sulD | BVIR_2636 | BVIR_2637 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional folate synthesis protein. | 0.999 |
| folE_1 | folB | BVIR_1779 | BVIR_2636 | GTP cyclohydrolase 1. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.965 |
| folE_1 | folP_1 | BVIR_1779 | BVIR_2635 | GTP cyclohydrolase 1. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.986 |
| folE_1 | ftsH_1 | BVIR_1779 | BVIR_2739 | GTP cyclohydrolase 1. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.957 |
| folE_1 | mazG | BVIR_1779 | BVIR_1640 | GTP cyclohydrolase 1. | Nucleoside triphosphate pyrophosphohydrolase. | 0.832 |
| folE_1 | moaA_1 | BVIR_1779 | BVIR_774 | GTP cyclohydrolase 1. | Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.910 |
| folE_1 | ndk_1 | BVIR_1779 | BVIR_1070 | GTP cyclohydrolase 1. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.851 |
| folE_1 | queD | BVIR_1779 | BVIR_1306 | GTP cyclohydrolase 1. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.989 |
| folE_1 | ribA | BVIR_1779 | BVIR_3035 | GTP cyclohydrolase 1. | GTP cyclohydrolase-2; In the N-terminal section; belongs to the DHBP synthase family. | 0.934 |
| folE_1 | ribBA_1 | BVIR_1779 | BVIR_1959 | GTP cyclohydrolase 1. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.944 |
| folE_1 | sulD | BVIR_1779 | BVIR_2637 | GTP cyclohydrolase 1. | Bifunctional folate synthesis protein. | 0.997 |
| folP_1 | folB | BVIR_2635 | BVIR_2636 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.999 |
| folP_1 | folE_1 | BVIR_2635 | BVIR_1779 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | GTP cyclohydrolase 1. | 0.986 |
| folP_1 | ftsH_1 | BVIR_2635 | BVIR_2739 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.491 |
| folP_1 | ribBA_1 | BVIR_2635 | BVIR_1959 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.462 |
| folP_1 | sulD | BVIR_2635 | BVIR_2637 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Bifunctional folate synthesis protein. | 0.999 |