| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BVIR_3289 | aroE | BVIR_3289 | BVIR_3285 | Hypothetical protein. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.454 |
| BVIR_3289 | hemE | BVIR_3289 | BVIR_3288 | Hypothetical protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.898 |
| BVIR_3289 | hemF | BVIR_3289 | BVIR_2487 | Hypothetical protein. | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.959 |
| BVIR_3289 | hemH | BVIR_3289 | BVIR_713 | Hypothetical protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.947 |
| BVIR_3289 | hemN_2 | BVIR_3289 | BVIR_2883 | Hypothetical protein. | Oxygen-independent coproporphyrinogen-III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.923 |
| aroE | BVIR_3289 | BVIR_3285 | BVIR_3289 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Hypothetical protein. | 0.454 |
| aroE | hemE | BVIR_3285 | BVIR_3288 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.650 |
| aroE | hemF | BVIR_3285 | BVIR_2487 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.665 |
| aroE | nadD | BVIR_3285 | BVIR_62 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Nicotinate-nucleotide adenylyltransferase. | 0.787 |
| hemB | hemC | BVIR_831 | BVIR_134 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
| hemB | hemE | BVIR_831 | BVIR_3288 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.828 |
| hemB | hemF | BVIR_831 | BVIR_2487 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.609 |
| hemB | hemH | BVIR_831 | BVIR_713 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.591 |
| hemC | hemB | BVIR_134 | BVIR_831 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.997 |
| hemC | hemE | BVIR_134 | BVIR_3288 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.991 |
| hemC | hemF | BVIR_134 | BVIR_2487 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.613 |
| hemC | hemH | BVIR_134 | BVIR_713 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.676 |
| hemE | BVIR_3289 | BVIR_3288 | BVIR_3289 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Hypothetical protein. | 0.898 |
| hemE | aroE | BVIR_3288 | BVIR_3285 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.650 |
| hemE | hemB | BVIR_3288 | BVIR_831 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.828 |