| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cca | ribD | BVIR_2491 | BVIR_2188 | CCA-adding enzyme; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.585 |
| cca | sulD | BVIR_2491 | BVIR_2637 | CCA-adding enzyme; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Bifunctional folate synthesis protein. | 0.761 |
| fgs | folB | BVIR_3242 | BVIR_2636 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.712 |
| fgs | folE_1 | BVIR_3242 | BVIR_1779 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase 1. | 0.712 |
| fgs | folP_1 | BVIR_3242 | BVIR_2635 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
| fgs | ispDF | BVIR_3242 | BVIR_1921 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.576 |
| fgs | ribD | BVIR_3242 | BVIR_2188 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.541 |
| fgs | sulD | BVIR_3242 | BVIR_2637 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Bifunctional folate synthesis protein. | 0.945 |
| fgs | trpE_2 | BVIR_3242 | BVIR_2862 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Anthranilate synthase component 1. | 0.539 |
| folB | fgs | BVIR_2636 | BVIR_3242 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.712 |
| folB | folE_1 | BVIR_2636 | BVIR_1779 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase 1. | 0.965 |
| folB | folP_1 | BVIR_2636 | BVIR_2635 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| folB | ispDF | BVIR_2636 | BVIR_1921 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.580 |
| folB | ribD | BVIR_2636 | BVIR_2188 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.577 |
| folB | sulD | BVIR_2636 | BVIR_2637 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional folate synthesis protein. | 0.999 |
| folB | trpE_2 | BVIR_2636 | BVIR_2862 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Anthranilate synthase component 1. | 0.539 |
| folE_1 | fgs | BVIR_1779 | BVIR_3242 | GTP cyclohydrolase 1. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.712 |
| folE_1 | folB | BVIR_1779 | BVIR_2636 | GTP cyclohydrolase 1. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.965 |
| folE_1 | folP_1 | BVIR_1779 | BVIR_2635 | GTP cyclohydrolase 1. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.986 |
| folE_1 | ispDF | BVIR_1779 | BVIR_1921 | GTP cyclohydrolase 1. | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). | 0.541 |