| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioB | hemA_1 | BVIR_1645 | BVIR_560 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. | 5-aminolevulinate synthase. | 0.932 |
| cobD | cobD-2 | BVIR_1291 | BVIR_1292 | Threonine-phosphate decarboxylase. | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.991 |
| cobD | hemA_1 | BVIR_1291 | BVIR_560 | Threonine-phosphate decarboxylase. | 5-aminolevulinate synthase. | 0.800 |
| cobD-2 | cobD | BVIR_1292 | BVIR_1291 | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Threonine-phosphate decarboxylase. | 0.991 |
| cobD-2 | hemA_1 | BVIR_1292 | BVIR_560 | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 5-aminolevulinate synthase. | 0.808 |
| fabD | hemA_1 | BVIR_672 | BVIR_560 | Malonyl CoA-acyl carrier protein transacylase. | 5-aminolevulinate synthase. | 0.930 |
| fabD | hemB | BVIR_672 | BVIR_831 | Malonyl CoA-acyl carrier protein transacylase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.777 |
| fabD | hemL_1 | BVIR_672 | BVIR_346 | Malonyl CoA-acyl carrier protein transacylase. | Beta-phenylalanine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.576 |
| gcvPA | gcvPB | BVIR_2687 | BVIR_2686 | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Putative glycine dehydrogenase (decarboxylating) subunit 2. | 0.999 |
| gcvPA | glyA2 | BVIR_2687 | BVIR_2190 | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
| gcvPA | hemA_1 | BVIR_2687 | BVIR_560 | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 5-aminolevulinate synthase. | 0.918 |
| gcvPA | soxB | BVIR_2687 | BVIR_2026 | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Sarcosine oxidase subunit beta. | 0.903 |
| gcvPB | gcvPA | BVIR_2686 | BVIR_2687 | Putative glycine dehydrogenase (decarboxylating) subunit 2. | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| gcvPB | glyA2 | BVIR_2686 | BVIR_2190 | Putative glycine dehydrogenase (decarboxylating) subunit 2. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.987 |
| gcvPB | hemA_1 | BVIR_2686 | BVIR_560 | Putative glycine dehydrogenase (decarboxylating) subunit 2. | 5-aminolevulinate synthase. | 0.929 |
| gcvPB | soxB | BVIR_2686 | BVIR_2026 | Putative glycine dehydrogenase (decarboxylating) subunit 2. | Sarcosine oxidase subunit beta. | 0.905 |
| glyA2 | gcvPA | BVIR_2190 | BVIR_2687 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.975 |
| glyA2 | gcvPB | BVIR_2190 | BVIR_2686 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glycine dehydrogenase (decarboxylating) subunit 2. | 0.987 |
| glyA2 | hemA_1 | BVIR_2190 | BVIR_560 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-aminolevulinate synthase. | 0.942 |
| glyA2 | soxB | BVIR_2190 | BVIR_2026 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Sarcosine oxidase subunit beta. | 0.910 |