| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BVIR_564 | BVIR_566 | BVIR_564 | BVIR_566 | Putative oxidoreductase. | Protoheme IX farnesyltransferase. | 0.998 |
| BVIR_564 | menA | BVIR_564 | BVIR_563 | Putative oxidoreductase. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.888 |
| BVIR_566 | BVIR_564 | BVIR_566 | BVIR_564 | Protoheme IX farnesyltransferase. | Putative oxidoreductase. | 0.998 |
| BVIR_566 | menA | BVIR_566 | BVIR_563 | Protoheme IX farnesyltransferase. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.478 |
| entC_1 | menA | BVIR_918 | BVIR_563 | Salicylate biosynthesis isochorismate synthase. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.465 |
| entC_1 | menB | BVIR_918 | BVIR_915 | Salicylate biosynthesis isochorismate synthase. | 1,4-Dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.923 |
| entC_1 | menD | BVIR_918 | BVIR_917 | Salicylate biosynthesis isochorismate synthase. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.967 |
| entC_1 | menH | BVIR_918 | BVIR_916 | Salicylate biosynthesis isochorismate synthase. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase. | 0.904 |
| entC_1 | ykfB | BVIR_918 | BVIR_914 | Salicylate biosynthesis isochorismate synthase. | L-Ala-D/L-Glu epimerase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. | 0.659 |
| ispB | menA | BVIR_2667 | BVIR_563 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.831 |
| ispB | ubiE_5 | BVIR_2667 | BVIR_3183 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.412 |
| menA | BVIR_564 | BVIR_563 | BVIR_564 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Putative oxidoreductase. | 0.888 |
| menA | BVIR_566 | BVIR_563 | BVIR_566 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Protoheme IX farnesyltransferase. | 0.478 |
| menA | entC_1 | BVIR_563 | BVIR_918 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Salicylate biosynthesis isochorismate synthase. | 0.465 |
| menA | ispB | BVIR_563 | BVIR_2667 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.831 |
| menA | menB | BVIR_563 | BVIR_915 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 1,4-Dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.853 |
| menA | menD | BVIR_563 | BVIR_917 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.878 |
| menA | menH | BVIR_563 | BVIR_916 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase. | 0.741 |
| menA | ubiE_1 | BVIR_563 | BVIR_562 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.905 |
| menA | ubiE_5 | BVIR_563 | BVIR_3183 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.905 |