| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbs_1 | glyA2 | BVIR_363 | BVIR_2190 | Putative cystathionine beta-synthase. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
| cbs_1 | ilvA_1 | BVIR_363 | BVIR_2884 | Putative cystathionine beta-synthase. | L-threonine dehydratase biosynthetic IlvA. | 0.930 |
| cbs_1 | serB_1 | BVIR_363 | BVIR_3017 | Putative cystathionine beta-synthase. | Phosphoserine phosphatase. | 0.949 |
| cbs_1 | tdcB | BVIR_363 | BVIR_952 | Putative cystathionine beta-synthase. | L-threonine dehydratase catabolic TdcB. | 0.930 |
| cbs_1 | trpA | BVIR_363 | BVIR_3244 | Putative cystathionine beta-synthase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.922 |
| cbs_1 | trpB_2 | BVIR_363 | BVIR_3245 | Putative cystathionine beta-synthase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.908 |
| glyA2 | cbs_1 | BVIR_2190 | BVIR_363 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative cystathionine beta-synthase. | 0.955 |
| glyA2 | ilvA_1 | BVIR_2190 | BVIR_2884 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase biosynthetic IlvA. | 0.914 |
| glyA2 | leuB_1 | BVIR_2190 | BVIR_3305 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.462 |
| glyA2 | serB_1 | BVIR_2190 | BVIR_3017 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.947 |
| glyA2 | tdcB | BVIR_2190 | BVIR_952 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase catabolic TdcB. | 0.914 |
| glyA2 | thrC_1 | BVIR_2190 | BVIR_3061 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine synthase. | 0.490 |
| glyA2 | trpA | BVIR_2190 | BVIR_3244 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
| glyA2 | trpB_2 | BVIR_2190 | BVIR_3245 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.935 |
| ilvA_1 | cbs_1 | BVIR_2884 | BVIR_363 | L-threonine dehydratase biosynthetic IlvA. | Putative cystathionine beta-synthase. | 0.930 |
| ilvA_1 | glyA2 | BVIR_2884 | BVIR_2190 | L-threonine dehydratase biosynthetic IlvA. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
| ilvA_1 | ilvH | BVIR_2884 | BVIR_3013 | L-threonine dehydratase biosynthetic IlvA. | Acetolactate synthase small subunit. | 0.964 |
| ilvA_1 | ilvI | BVIR_2884 | BVIR_3014 | L-threonine dehydratase biosynthetic IlvA. | Acetolactate synthase isozyme 3 large subunit. | 0.936 |
| ilvA_1 | leuB_1 | BVIR_2884 | BVIR_3305 | L-threonine dehydratase biosynthetic IlvA. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.938 |
| ilvA_1 | serB_1 | BVIR_2884 | BVIR_3017 | L-threonine dehydratase biosynthetic IlvA. | Phosphoserine phosphatase. | 0.912 |