AFV10967.1 protein (Thermacetogenium phaeum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

AFV10967.1

Hypothetical protein. (131 aa)

Predicted Functional Partners:

AFV10968.1

0.961

AFV10965.1

0.918

AFV10966.1

0.918

AFV10970.1

0.900

AFV10961.1

0.898

AFV10964.1

0.898

AFV10963.1

0.892

AFV10962.1

0.887

AFV10956.1

0.820

AFV10981.1

0.800

Your Current Organism:

Thermacetogenium phaeum

NCBI taxonomy Id: 1089553
Other names: Clostridiaceae str. PB, T. phaeum DSM 12270, Thermacetogenium phaeum DSM 12270, Thermacetogenium phaeum PB, Thermacetogenium phaeum str. DSM 12270, Thermacetogenium phaeum strain DSM 12270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFV10956.1	AFV10961.1	Tph_c07240	Tph_c07290	Hypothetical protein.	A24A-like peptidase.	0.831
AFV10956.1	AFV10962.1	Tph_c07240	Tph_c07300	Hypothetical protein.	CpaB-like pilus assembly protein.	0.817
AFV10956.1	AFV10963.1	Tph_c07240	Tph_c07310	Hypothetical protein.	Cobyrinic acid a,c-diamide synthase.	0.831
AFV10956.1	AFV10964.1	Tph_c07240	Tph_c07320	Hypothetical protein.	Type II secretion system protein E.	0.788
AFV10956.1	AFV10965.1	Tph_c07240	Tph_c07330	Hypothetical protein.	Hypothetical protein.	0.842
AFV10956.1	AFV10966.1	Tph_c07240	Tph_c07340	Hypothetical protein.	Hypothetical protein.	0.820
AFV10956.1	AFV10967.1	Tph_c07240	Tph_c07350	Hypothetical protein.	Hypothetical protein.	0.820
AFV10956.1	AFV10968.1	Tph_c07240	Tph_c07360	Hypothetical protein.	Hypothetical protein.	0.817
AFV10956.1	AFV10970.1	Tph_c07240	Tph_c07380	Hypothetical protein.	Hypothetical protein.	0.809
AFV10956.1	AFV10981.1	Tph_c07240	Tph_c07490	Hypothetical protein.	Putative P-loop containing nucleoside triphosphate hydrolase.	0.813
AFV10961.1	AFV10956.1	Tph_c07290	Tph_c07240	A24A-like peptidase.	Hypothetical protein.	0.831
AFV10961.1	AFV10962.1	Tph_c07290	Tph_c07300	A24A-like peptidase.	CpaB-like pilus assembly protein.	0.947
AFV10961.1	AFV10963.1	Tph_c07290	Tph_c07310	A24A-like peptidase.	Cobyrinic acid a,c-diamide synthase.	0.946
AFV10961.1	AFV10964.1	Tph_c07290	Tph_c07320	A24A-like peptidase.	Type II secretion system protein E.	0.950
AFV10961.1	AFV10965.1	Tph_c07290	Tph_c07330	A24A-like peptidase.	Hypothetical protein.	0.954
AFV10961.1	AFV10966.1	Tph_c07290	Tph_c07340	A24A-like peptidase.	Hypothetical protein.	0.954
AFV10961.1	AFV10967.1	Tph_c07290	Tph_c07350	A24A-like peptidase.	Hypothetical protein.	0.898
AFV10961.1	AFV10968.1	Tph_c07290	Tph_c07360	A24A-like peptidase.	Hypothetical protein.	0.898
AFV10961.1	AFV10970.1	Tph_c07290	Tph_c07380	A24A-like peptidase.	Hypothetical protein.	0.838
AFV10961.1	AFV10981.1	Tph_c07290	Tph_c07490	A24A-like peptidase.	Putative P-loop containing nucleoside triphosphate hydrolase.	0.783

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006620

Post-translational protein targeting to endoplasmic reticulum membrane

7 of 15

2.83

7.49

4.25e-15

GO:0031204

Post-translational protein targeting to membrane, translocation

6 of 8

3.03

6.94

1.18e-13

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

3 of 12

2.56

1.62e-05

GO:0008104

Protein localization

8 of 496

1.37

2.02

3.55e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

2 of 4

2.86

1.69

0.00084

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

5 of 16

2.65

4.58

1.87e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030867

Rough endoplasmic reticulum membrane

6 of 10

2.94

6.83

1.45e-13

GO:0140534

Endoplasmic reticulum protein-containing complex

6 of 83

2.02

3.73

3.43e-09

GO:0071256

Translocon complex

3 of 3

3.16

3.45

5.32e-07

GO:0031207

Sec62/Sec63 complex

3 of 5

2.94

3.21

1.32e-06

GO:0005789

Endoplasmic reticulum membrane

7 of 347

1.46

2.14

1.73e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19150

Post-translational protein targeting to membrane, translocation

6 of 6

3.16

7.39

2.25e-14

CL:19146

Rough endoplasmic reticulum, and Signal peptidase complex

7 of 17

2.77

7.38

5.33e-15

CL:4562

Nucleotide-activated protein kinase complex, and Energy dependent regulation of mTOR by LKB1-AMPK

2 of 13

2.34

1.02

0.0132

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

5 of 34

2.32

4.11

4.88e-09

map04141

Protein processing in endoplasmic reticulum

5 of 270

1.43

1.57

4.97e-05

map04145

Phagosome

3 of 73

1.77

1.46

0.00087

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-380972

Energy dependent regulation of mTOR by LKB1-AMPK

3 of 17

2.4

1.9

0.00027

MAP-165159

MTOR signalling

3 of 28

2.19

1.71

0.00053

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

2 of 13

2.34

1.0

0.0147

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030867

Rough endoplasmic reticulum membrane

6 of 14

2.79

6.34

8.28e-13

GOCC:0005789

Endoplasmic reticulum membrane

7 of 154

1.82

3.45

1.06e-09

GOCC:0071256

Translocon complex

3 of 3

3.16

3.38

7.20e-07

GOCC:0031207

Sec62/Sec63 complex

3 of 5

2.94

3.14

1.76e-06

GOCC:0005783

Endoplasmic reticulum

7 of 320

1.5

2.28

7.82e-08

(more ...)

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