STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sir2NAD-dependent histone deacetylase silent information regulator Sir2. (250 aa)    
Predicted Functional Partners:
nadE1
Glutamine-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.944
nadD
Nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.931
ldh
Leucine dehydrogenase Ldh; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.911
ppnK1
Inorganic polyphosphate/ATP-NAD kinase PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
 
 0.909
nadE2
NH(3)-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
    
 0.909
ppnK2
Inorganic polyphosphate/ATP-NAD kinase PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
 
 0.909
nadE3
NH(3)-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.909
pntAA1
NAD(P) transhydrogenase subunit alpha, part 2.
     
 0.904
pntAA2
NAD(P) transhydrogenase subunit alpha, part 1.
     
 0.904
pntB
NAD(P) transhydrogenase subunit beta.
     
  0.900
Your Current Organism:
Thermacetogenium phaeum
NCBI taxonomy Id: 1089553
Other names: Clostridiaceae str. PB, T. phaeum DSM 12270, Thermacetogenium phaeum DSM 12270, Thermacetogenium phaeum PB, Thermacetogenium phaeum str. DSM 12270, Thermacetogenium phaeum strain DSM 12270
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.