node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFV12174.1 | ilvB | Tph_c19800 | Tph_c19870 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase large subunit IlvB. | 0.939 |
AFV12174.1 | ilvC | Tph_c19800 | Tph_c19850 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate. | 0.857 |
AFV12174.1 | ilvD | Tph_c19800 | Tph_c19880 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | 0.981 |
AFV12174.1 | ilvH | Tph_c19800 | Tph_c19860 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase small subunit IlvH. | 0.951 |
AFV12174.1 | leuA2 | Tph_c19800 | Tph_c19840 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.965 |
AFV12174.1 | leuB1 | Tph_c19800 | Tph_c09030 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Isocitrate/isopropylmalate dehydrogenase LeuB. | 0.578 |
AFV12174.1 | leuB2 | Tph_c19800 | Tph_c19810 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.842 |
AFV12174.1 | leuC2 | Tph_c19800 | Tph_c19830 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.976 |
AFV12174.1 | leuD1 | Tph_c19800 | Tph_c09020 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit 2; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.954 |
AFV12174.1 | leuD2 | Tph_c19800 | Tph_c19820 | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.984 |
ilvB | AFV12174.1 | Tph_c19870 | Tph_c19800 | Acetolactate synthase large subunit IlvB. | IPM/Hcit synthase-like protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.939 |
ilvB | ilvC | Tph_c19870 | Tph_c19850 | Acetolactate synthase large subunit IlvB. | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
ilvB | ilvD | Tph_c19870 | Tph_c19880 | Acetolactate synthase large subunit IlvB. | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | 0.998 |
ilvB | ilvH | Tph_c19870 | Tph_c19860 | Acetolactate synthase large subunit IlvB. | Acetolactate synthase small subunit IlvH. | 0.999 |
ilvB | leuA2 | Tph_c19870 | Tph_c19840 | Acetolactate synthase large subunit IlvB. | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.984 |
ilvB | leuB1 | Tph_c19870 | Tph_c09030 | Acetolactate synthase large subunit IlvB. | Isocitrate/isopropylmalate dehydrogenase LeuB. | 0.666 |
ilvB | leuB2 | Tph_c19870 | Tph_c19810 | Acetolactate synthase large subunit IlvB. | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.995 |
ilvB | leuC2 | Tph_c19870 | Tph_c19830 | Acetolactate synthase large subunit IlvB. | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.898 |
ilvB | leuD1 | Tph_c19870 | Tph_c09020 | Acetolactate synthase large subunit IlvB. | 3-isopropylmalate dehydratase small subunit 2; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.664 |
ilvB | leuD2 | Tph_c19870 | Tph_c19820 | Acetolactate synthase large subunit IlvB. | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.925 |