mtbC protein (Thermacetogenium phaeum) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

mtbC

Dimethylamine corrinoid protein MtbC. (216 aa)

Predicted Functional Partners:

metH1

0.962

metH2

0.960

AFV10429.1

0.956

metH3

0.954

acsE

0.929

AFV12206.1

0.682

mtaB

0.556

AFV12205.1

0.484

deoC

0.434

AFV12652.1

0.424

Your Current Organism:

Thermacetogenium phaeum

NCBI taxonomy Id: 1089553
Other names: Clostridiaceae str. PB, T. phaeum DSM 12270, Thermacetogenium phaeum DSM 12270, Thermacetogenium phaeum PB, Thermacetogenium phaeum str. DSM 12270, Thermacetogenium phaeum strain DSM 12270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFV10429.1	acsE	Tph_c01810	Tph_c15130	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase AcsE.	0.909
AFV10429.1	metH3	Tph_c01810	Tph_c27600	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.	Methionine synthase MetH.	0.908
AFV10429.1	mtbC	Tph_c01810	Tph_c20130	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.	Dimethylamine corrinoid protein MtbC.	0.956
AFV12205.1	AFV12206.1	Tph_c20110	Tph_c20120	IS116/IS110/IS902-like transposase.	Hypothetical protein.	0.543
AFV12205.1	mtbC	Tph_c20110	Tph_c20130	IS116/IS110/IS902-like transposase.	Dimethylamine corrinoid protein MtbC.	0.484
AFV12206.1	AFV12205.1	Tph_c20120	Tph_c20110	Hypothetical protein.	IS116/IS110/IS902-like transposase.	0.543
AFV12206.1	mtbC	Tph_c20120	Tph_c20130	Hypothetical protein.	Dimethylamine corrinoid protein MtbC.	0.682
AFV12652.1	mtbC	Tph_c24780	Tph_c20130	Putative ferredoxin.	Dimethylamine corrinoid protein MtbC.	0.424
acsE	AFV10429.1	Tph_c15130	Tph_c01810	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase AcsE.	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.	0.909
acsE	metH3	Tph_c15130	Tph_c27600	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase AcsE.	Methionine synthase MetH.	0.914
acsE	mtbC	Tph_c15130	Tph_c20130	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase AcsE.	Dimethylamine corrinoid protein MtbC.	0.929
deoC	mtbC	Tph_c22680	Tph_c20130	Deoxyribose-phosphate aldolase DeoC; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.	Dimethylamine corrinoid protein MtbC.	0.434
metH1	metH2	Tph_c03610	Tph_c05890	Methionine synthase MetH.	Methionine synthase MetH.	0.904
metH1	mtaB	Tph_c03610	Tph_c03590	Methionine synthase MetH.	Methanol-cobalamin methyltransferase, subunit beta.	0.530
metH1	mtbC	Tph_c03610	Tph_c20130	Methionine synthase MetH.	Dimethylamine corrinoid protein MtbC.	0.962
metH2	metH1	Tph_c05890	Tph_c03610	Methionine synthase MetH.	Methionine synthase MetH.	0.904
metH2	mtbC	Tph_c05890	Tph_c20130	Methionine synthase MetH.	Dimethylamine corrinoid protein MtbC.	0.960
metH3	AFV10429.1	Tph_c27600	Tph_c01810	Methionine synthase MetH.	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.	0.908
metH3	acsE	Tph_c27600	Tph_c15130	Methionine synthase MetH.	Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase AcsE.	0.914
metH3	mtbC	Tph_c27600	Tph_c20130	Methionine synthase MetH.	Dimethylamine corrinoid protein MtbC.	0.954

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.934

expected number of edges:

10

PPI enrichment p-value:

5.09e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 105

1.33

2.33

3.59e-12

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 53

1.63

3.85

1.93e-15

GO:0019843

rRNA binding

6 of 41

1.48

1.89

4.28e-06

GO:0003723

RNA binding

7 of 100

1.16

1.28

1.59e-05

GO:0000049

tRNA binding

3 of 23

1.43

0.77

0.0220

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 56

1.61

3.8

6.09e-16

GO:0015935

Small ribosomal subunit

4 of 7

2.07

2.79

1.56e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:140

Ribosome

11 of 57

1.6

3.67

3.73e-15

CL:148

Structural constituent of ribosome

7 of 27

1.73

3.24

9.17e-10

CL:184

Mixed, incl. Small ribosomal subunit, and Ribosomal protein S13-like, H2TH

4 of 7

2.07

2.68

2.83e-06

CL:216

Ribosome

4 of 11

1.87

2.27

1.09e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

laca03010

Ribosome

11 of 53

1.63

3.94

3.53e-16

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

10 of 44

1.67

3.83

5.43e-14

GOCC:0015935

Small ribosomal subunit

6 of 13

1.98

3.69

2.69e-09

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 11

1.97

3.15

9.09e-08

GOCC:0043229

Intracellular organelle

11 of 252

0.95

1.16

2.16e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 55

1.61

3.82

9.29e-16

KW-0699

rRNA-binding

6 of 38

1.51

2.09

9.41e-07

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