panB protein (Thermacetogenium phaeum) - STRING interaction network

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Known Interactions

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Predicted Interactions

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panB

3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (265 aa)

Predicted Functional Partners:

panC

0.999

panD

0.980

ilvD

0.927

ilvE1

0.909

ilvE2

0.909

AFV12841.1

0.907

folK

0.856

birA

0.821

nadC

0.738

guaA

0.696

Your Current Organism:

Thermacetogenium phaeum

NCBI taxonomy Id: 1089553
Other names: Clostridiaceae str. PB, T. phaeum DSM 12270, Thermacetogenium phaeum DSM 12270, Thermacetogenium phaeum PB, Thermacetogenium phaeum str. DSM 12270, Thermacetogenium phaeum strain DSM 12270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFV12841.1	birA	Tph_c26730	Tph_c26600	Putative NAD(P) dependent oxidoreductase.	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.404
AFV12841.1	folK	Tph_c26730	Tph_c26740	Putative NAD(P) dependent oxidoreductase.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	0.516
AFV12841.1	panB	Tph_c26730	Tph_c26720	Putative NAD(P) dependent oxidoreductase.	3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.907
AFV12841.1	panC	Tph_c26730	Tph_c26710	Putative NAD(P) dependent oxidoreductase.	Pantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.955
AFV12841.1	panD	Tph_c26730	Tph_c26700	Putative NAD(P) dependent oxidoreductase.	Aspartate 1-decarboxylase PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.791
birA	AFV12841.1	Tph_c26600	Tph_c26730	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Putative NAD(P) dependent oxidoreductase.	0.404
birA	folK	Tph_c26600	Tph_c26740	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	0.687
birA	guaA	Tph_c26600	Tph_c08410	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	GMP synthase GuaA; Catalyzes the synthesis of GMP from XMP.	0.795
birA	ilvE1	Tph_c26600	Tph_c19890	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Branched-chain-amino-acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.416
birA	ilvE2	Tph_c26600	Tph_c20540	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Putative branched-chain-amino-acid aminotransferase IlvE.	0.416
birA	nadC	Tph_c26600	Tph_c26610	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Nicotinate-nucleotide pyrophosphorylase; Carboxylating; Belongs to the NadC/ModD family.	0.903
birA	panB	Tph_c26600	Tph_c26720	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.821
birA	panC	Tph_c26600	Tph_c26710	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Pantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.799
birA	panD	Tph_c26600	Tph_c26700	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Aspartate 1-decarboxylase PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.765
folK	AFV12841.1	Tph_c26740	Tph_c26730	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	Putative NAD(P) dependent oxidoreductase.	0.516
folK	birA	Tph_c26740	Tph_c26600	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.687
folK	panB	Tph_c26740	Tph_c26720	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.	0.856
folK	panC	Tph_c26740	Tph_c26710	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	Pantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.	0.583
folK	panD	Tph_c26740	Tph_c26700	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK.	Aspartate 1-decarboxylase PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.	0.444
guaA	birA	Tph_c08410	Tph_c26600	GMP synthase GuaA; Catalyzes the synthesis of GMP from XMP.	biotin--acetyl-CoA-carboxylase ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.795

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Network Stats

number of nodes:

10

number of edges:

16

average node degree:

3.2

avg. local clustering coefficient:

0.869

expected number of edges:

9

PPI enrichment p-value:

0.0237

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019430

Removal of superoxide radicals

2 of 4

2.58

1.17

0.0072

GO:0006537

Glutamate biosynthetic process

2 of 4

2.58

1.17

0.0072

GO:0098869

Cellular oxidant detoxification

3 of 25

1.96

1.11

0.0072

GO:0006541

Glutamine metabolic process

2 of 23

1.82

0.84

0.0235

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051538

3 iron, 4 sulfur cluster binding

2 of 2

2.88

1.48

0.0021

GO:0016041

Glutamate synthase (ferredoxin) activity

2 of 2

2.88

1.48

0.0021

GO:0004791

Thioredoxin-disulfide reductase activity

2 of 2

2.88

1.48

0.0021

GO:0015035

Protein-disulfide reductase activity

3 of 17

2.12

1.47

0.0015

GO:0016491

Oxidoreductase activity

6 of 436

1.02

0.81

0.0021

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

5 of 22

2.23

3.8

1.46e-08

map00910

Nitrogen metabolism

3 of 28

1.91

1.62

0.00050

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 53

1.76

2.16

1.08e-05

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 110

1.44

1.52

8.77e-05

MAP-5663205

Infectious disease

4 of 117

1.41

1.49

8.77e-05

MAP-1643685

Disease

4 of 120

1.4

1.48

8.77e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.88

1.18

0.0074

PF01493

GXGXG motif

2 of 2

2.88

1.18

0.0074

PF00310

Glutamine amidotransferases class-II

2 of 2

2.88

1.18

0.0074

PF01645

Conserved region in glutamate synthase

2 of 3

2.7

1.17

0.0074

PF00890

FAD binding domain

2 of 12

2.1

0.88

0.0222

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023753

FAD/NAD(P)-binding domain

4 of 15

2.3

2.54

1.21e-05

IPR036188

FAD/NAD(P)-binding domain superfamily

4 of 52

1.76

1.53

0.00056

IPR036485

Glutamate synthase, alpha subunit, C-terminal domain superfamily

2 of 2

2.88

1.23

0.0060

IPR006982

Glutamate synthase, central-N

2 of 2

2.88

1.23

0.0060

IPR002932

Glutamate synthase domain

2 of 2

2.88

1.23

0.0060

(more ...)

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