Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
addAATP-dependent helicase/nuclease subunit A. (847 aa)    
Predicted Functional Partners:
CEO17626.1
PD-(D/E)XK nuclease superfamily protein.
 
   
 0.919
CEO17532.1
Hypothetical protein.
  
 
 0.858
CEO17774.1
Hypothetical protein.
  
 
 0.858
CEO17775.1
Hypothetical protein.
  
 
 0.858
pcrA
ATP-dependent DNA helicase PcrA.
 
  
0.855
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.850
pheT
Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.811
ogt
Methylated-DNA--protein-cysteine methyltransferase.
     
 0.805
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
   
 0.726
ruvA
Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
  
 0.688
Your Current Organism:
Rickettsia monacensis
NCBI taxonomy Id: 109232
Other names: R. monacensis, Rickettsia sp. IrR/Munich, strain IrR/Munich
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