ENSHCOP00000002121 protein (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSHCOP00000002121

CortBP2 domain-containing protein. (1051 aa)

Predicted Functional Partners:

trappc1

0.790

trappc8

0.771

TRAPPC5

0.752

trappc6b

0.750

trappc2

0.745

trappc3

0.695

LOC109524812

0.695

uso1

0.694

stx5

0.643

rabggtb

0.643

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000002121	LOC109524812	ENSHCOP00000002121	ENSHCOP00000005846	CortBP2 domain-containing protein.	Lebercilin LCA5.	0.695
ENSHCOP00000002121	TRAPPC5	ENSHCOP00000002121	ENSHCOP00000015775	CortBP2 domain-containing protein.	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.752
ENSHCOP00000002121	rabggtb	ENSHCOP00000002121	ENSHCOP00000021871	CortBP2 domain-containing protein.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.643
ENSHCOP00000002121	stx5	ENSHCOP00000002121	ENSHCOP00000017020	CortBP2 domain-containing protein.	Syntaxin 5A; Belongs to the syntaxin family.	0.643
ENSHCOP00000002121	trappc1	ENSHCOP00000002121	ENSHCOP00000007248	CortBP2 domain-containing protein.	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.	0.790
ENSHCOP00000002121	trappc2	ENSHCOP00000002121	ENSHCOP00000002863	CortBP2 domain-containing protein.	Trafficking protein particle complex 2.	0.745
ENSHCOP00000002121	trappc3	ENSHCOP00000002121	ENSHCOP00000002501	CortBP2 domain-containing protein.	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.695
ENSHCOP00000002121	trappc6b	ENSHCOP00000002121	ENSHCOP00000012732	CortBP2 domain-containing protein.	Trafficking protein particle complex 6b-like.	0.750
ENSHCOP00000002121	trappc8	ENSHCOP00000002121	ENSHCOP00000006100	CortBP2 domain-containing protein.	Trafficking protein particle complex 8.	0.771
ENSHCOP00000002121	uso1	ENSHCOP00000002121	ENSHCOP00000003415	CortBP2 domain-containing protein.	USO1 vesicle transport factor.	0.694
LOC109524812	ENSHCOP00000002121	ENSHCOP00000005846	ENSHCOP00000002121	Lebercilin LCA5.	CortBP2 domain-containing protein.	0.695
LOC109524812	TRAPPC5	ENSHCOP00000005846	ENSHCOP00000015775	Lebercilin LCA5.	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.982
LOC109524812	stx5	ENSHCOP00000005846	ENSHCOP00000017020	Lebercilin LCA5.	Syntaxin 5A; Belongs to the syntaxin family.	0.750
LOC109524812	trappc1	ENSHCOP00000005846	ENSHCOP00000007248	Lebercilin LCA5.	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.	0.975
LOC109524812	trappc2	ENSHCOP00000005846	ENSHCOP00000002863	Lebercilin LCA5.	Trafficking protein particle complex 2.	0.975
LOC109524812	trappc6b	ENSHCOP00000005846	ENSHCOP00000012732	Lebercilin LCA5.	Trafficking protein particle complex 6b-like.	0.976
LOC109524812	trappc8	ENSHCOP00000005846	ENSHCOP00000006100	Lebercilin LCA5.	Trafficking protein particle complex 8.	0.975
LOC109524812	uso1	ENSHCOP00000005846	ENSHCOP00000003415	Lebercilin LCA5.	USO1 vesicle transport factor.	0.471
TRAPPC5	ENSHCOP00000002121	ENSHCOP00000015775	ENSHCOP00000002121	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	CortBP2 domain-containing protein.	0.752
TRAPPC5	LOC109524812	ENSHCOP00000015775	ENSHCOP00000005846	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	Lebercilin LCA5.	0.982

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.875

expected number of edges:

11

PPI enrichment p-value:

4.94e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 38

1.96

4.42

8.65e-12

GO:0071555

Cell wall organization

4 of 26

1.83

2.07

2.98e-05

GO:0008360

Regulation of cell shape

4 of 26

1.83

2.07

2.98e-05

GO:0051301

Cell division

3 of 44

1.47

0.99

0.0063

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008955

Peptidoglycan glycosyltransferase activity

5 of 7

2.49

4.05

1.40e-08

GO:0008658

Penicillin binding

4 of 6

2.46

3.21

7.03e-07

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

3 of 5

2.42

2.34

3.71e-05

GO:0016757

Glycosyltransferase activity

6 of 61

1.63

2.33

7.03e-07

GO:0004180

Carboxypeptidase activity

4 of 19

1.96

2.32

1.32e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1359

Mixed, incl. Peptidoglycan biosynthesis, and Cell division

11 of 46

2.02

6.54

2.68e-19

CL:1363

Mixed, incl. Peptidoglycan biosynthesis, and Cell division site

9 of 33

2.07

5.85

1.83e-15

CL:1416

Peptidoglycan glycosyltransferase activity, and Peptidoglycan muralytic activity

4 of 5

2.54

3.48

2.33e-07

CL:1365

Mixed, incl. Cell shape, and Cell division site

5 of 23

1.98

3.01

2.35e-07

CL:1398

Mixed, incl. Cell cycle protein, and Cell morphogenesis

2 of 5

2.24

1.07

0.0102

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 33

1.9

3.33

1.15e-08

map01501

beta-Lactam resistance

4 of 121

1.16

0.79

0.0083

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 9

2.16

1.68

0.00059

GOCC:0005618

Cell wall

3 of 21

1.79

1.26

0.0027

GOCC:0071944

Cell periphery

7 of 713

0.63

0.39

0.0319

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

3 of 16

1.91

1.38

0.0018

KW-0133

Cell shape

3 of 16

1.91

1.38

0.0018

KW-0997

Cell inner membrane

3 of 42

1.49

0.94

0.0087

KW-0573

Peptidoglycan synthesis

2 of 15

1.76

0.87

0.0198

KW-0328

Glycosyltransferase

2 of 22

1.6

0.73

0.0348

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 6

2.46

2.98

2.11e-06

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.64

1.11

0.0097

PF01098

Cell cycle protein

2 of 2

2.64

1.11

0.0097

PF00912

Transglycosylase

2 of 4

2.34

1.04

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 6

2.46

2.92

2.73e-06

IPR012338

Beta-lactamase/transpeptidase-like

5 of 18

2.08

2.84

1.26e-06

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 2

2.64

0.98

0.0167

IPR005311

Penicillin-binding protein, dimerisation domain

2 of 2

2.64

0.98

0.0167

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

2 of 2

2.64

0.98

0.0167

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About