STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (983 aa)    
Predicted Functional Partners:
grpel1
GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.
  
  
 0.895
CLPB
ClpB homolog, mitochondrial AAA ATPase chaperonin.
  
 
 0.888
clpx
Caseinolytic mitochondrial matrix peptidase chaperone subunit b.
 
 
 0.812
clpp
ATP-dependent Clp protease proteolytic subunit.
  
 
 0.810
tysnd1
Trypsin domain containing 1.
   
 0.744
hspd1
Heat shock 60 protein 1; Belongs to the chaperonin (HSP60) family.
  
 0.718
Atm
TAN domain-containing protein.
      
 0.690
LOC109513386
Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.690
ALDH18A1
Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.690
pex5l
Peroxisomal biogenesis factor 5-like a.
   
 0.663
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.