STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scn8aSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1681 aa)    
Predicted Functional Partners:
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.989
Scn2b
Sodium channel, voltage-gated, type II, beta.
   
 0.856
LOC109512107
Sodium channel, voltage-gated, type I, beta a.
   
 0.761
LOC109513576
Sodium channel, voltage-gated, type I, beta b.
   
 0.700
ENSHCOP00000021585
Uncharacterized protein.
   
 0.700
LOC109513575
Ig-like domain-containing protein.
   
 0.700
wdr35
WD repeat-containing protein 35.
    
 0.657
IFT122
Intraflagellar transport 122.
   
 0.645
wdr19
WD repeat domain 19.
    
 0.633
scn3b
Sodium channel, voltage-gated, type III, beta.
   
 0.632
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.