node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC109520279 | LOC109528457 | ENSHCOP00000005285 | ENSHCOP00000022970 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.858 |
LOC109520279 | LOC109529328 | ENSHCOP00000005285 | ENSHCOP00000011535 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.507 |
LOC109520279 | sumo1 | ENSHCOP00000005285 | ENSHCOP00000008810 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier. | 0.997 |
LOC109520279 | ube2i | ENSHCOP00000005285 | ENSHCOP00000012367 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | 0.900 |
LOC109528457 | LOC109520279 | ENSHCOP00000022970 | ENSHCOP00000005285 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.858 |
LOC109528457 | LOC109529328 | ENSHCOP00000022970 | ENSHCOP00000011535 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.664 |
LOC109528457 | PLK1 | ENSHCOP00000022970 | ENSHCOP00000023113 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Serine/threonine-protein kinase PLK. | 0.688 |
LOC109528457 | pin1 | ENSHCOP00000022970 | ENSHCOP00000023163 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Peptidyl-prolyl cis-trans isomerase. | 0.836 |
LOC109528457 | plk3 | ENSHCOP00000022970 | ENSHCOP00000022015 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Serine/threonine-protein kinase PLK. | 0.688 |
LOC109528457 | sumo1 | ENSHCOP00000022970 | ENSHCOP00000008810 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Small ubiquitin-related modifier. | 0.847 |
LOC109528457 | ube2i | ENSHCOP00000022970 | ENSHCOP00000012367 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | 0.858 |
LOC109529328 | LOC109520279 | ENSHCOP00000011535 | ENSHCOP00000005285 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.507 |
LOC109529328 | LOC109528457 | ENSHCOP00000011535 | ENSHCOP00000022970 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.664 |
LOC109529328 | PLK1 | ENSHCOP00000011535 | ENSHCOP00000023113 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase PLK. | 0.468 |
LOC109529328 | cbfb | ENSHCOP00000011535 | ENSHCOP00000025408 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Core-binding factor subunit beta. | 0.499 |
LOC109529328 | dcaf7 | ENSHCOP00000011535 | ENSHCOP00000018452 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | DDB1 and CUL4 associated factor 7. | 0.700 |
LOC109529328 | mecp2 | ENSHCOP00000011535 | ENSHCOP00000012873 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Methyl CpG binding protein 2. | 0.510 |
LOC109529328 | pin1 | ENSHCOP00000011535 | ENSHCOP00000023163 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Peptidyl-prolyl cis-trans isomerase. | 0.540 |
LOC109529328 | plk3 | ENSHCOP00000011535 | ENSHCOP00000022015 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase PLK. | 0.468 |
LOC109529328 | sumo1 | ENSHCOP00000011535 | ENSHCOP00000008810 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Small ubiquitin-related modifier. | 0.533 |