STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC109517974Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)    
Predicted Functional Partners:
fgfr2
Fibroblast growth factor receptor.
    
 0.949
LOC109518129
Fibroblast growth factor receptor 4.
    
 0.921
ENSHCOP00000023562
Uncharacterized protein.
    
 0.913
LOC109514643
Uncharacterized protein.
    
 
 0.904
pdgfra
Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 0.809
flt3
Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.809
LOC109511602
Fibroblast growth factor receptor.
    
 0.799
fgfr3
Fibroblast growth factor receptor.
    
 0.783
pdgfrb
Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 0.777
LOC109516590
Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 0.766
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.