STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chek2Checkpoint kinase 2. (518 aa)    
Predicted Functional Partners:
Atr
Uncharacterized protein.
    
 0.996
LOC109528457
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.995
Atm
TAN domain-containing protein.
    
 0.994
cdc25b
Rhodanese domain-containing protein.
   
 0.994
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
0.993
tp53bp1
Tumor protein p53 binding protein, 1.
    
 0.982
cdc7
Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily.
    
 
0.954
brca1
Uncharacterized protein.
   
 0.950
dbf4
DBF4-type domain-containing protein.
    
 
 0.943
ASF1B
Anti-silencing function 1Bb histone chaperone.
   
 
 0.943
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.