aven protein (Hippocampus comes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

aven

Apoptosis, caspase activation inhibitor. (268 aa)

Predicted Functional Partners:

Apaf1

0.977

ENSHCOP00000023803

0.810

LOC109516977

0.699

tpx2

0.699

bcl2l1

0.646

casp9

0.591

sec63

0.586

WDR7

0.537

Wdr61

0.537

gemin5

0.537

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Apaf1	ENSHCOP00000023803	ENSHCOP00000020680	ENSHCOP00000023803	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.574
Apaf1	aven	ENSHCOP00000020680	ENSHCOP00000019805	Apoptotic peptidase activating factor 1.	Apoptosis, caspase activation inhibitor.	0.977
Apaf1	bcl2l1	ENSHCOP00000020680	ENSHCOP00000021075	Apoptotic peptidase activating factor 1.	BCL2 like 1.	0.853
Apaf1	casp9	ENSHCOP00000020680	ENSHCOP00000004962	Apoptotic peptidase activating factor 1.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.988
ENSHCOP00000023803	Apaf1	ENSHCOP00000023803	ENSHCOP00000020680	Uncharacterized protein.	Apoptotic peptidase activating factor 1.	0.574
ENSHCOP00000023803	LOC109516977	ENSHCOP00000023803	ENSHCOP00000003779	Uncharacterized protein.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.488
ENSHCOP00000023803	aven	ENSHCOP00000023803	ENSHCOP00000019805	Uncharacterized protein.	Apoptosis, caspase activation inhibitor.	0.810
ENSHCOP00000023803	bcl2l1	ENSHCOP00000023803	ENSHCOP00000021075	Uncharacterized protein.	BCL2 like 1.	0.543
ENSHCOP00000023803	casp9	ENSHCOP00000023803	ENSHCOP00000004962	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.627
ENSHCOP00000023803	tpx2	ENSHCOP00000023803	ENSHCOP00000011341	Uncharacterized protein.	TPX2 microtubule nucleation factor.	0.488
LOC109516977	ENSHCOP00000023803	ENSHCOP00000003779	ENSHCOP00000023803	Cystatin domain-containing protein; Belongs to the cystatin family.	Uncharacterized protein.	0.488
LOC109516977	aven	ENSHCOP00000003779	ENSHCOP00000019805	Cystatin domain-containing protein; Belongs to the cystatin family.	Apoptosis, caspase activation inhibitor.	0.699
LOC109516977	bcl2l1	ENSHCOP00000003779	ENSHCOP00000021075	Cystatin domain-containing protein; Belongs to the cystatin family.	BCL2 like 1.	0.475
LOC109516977	casp9	ENSHCOP00000003779	ENSHCOP00000004962	Cystatin domain-containing protein; Belongs to the cystatin family.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.471
WDR7	aven	ENSHCOP00000001833	ENSHCOP00000019805	WD repeat domain 7.	Apoptosis, caspase activation inhibitor.	0.537
Wdr61	aven	ENSHCOP00000005682	ENSHCOP00000019805	WD repeat domain 61.	Apoptosis, caspase activation inhibitor.	0.537
aven	Apaf1	ENSHCOP00000019805	ENSHCOP00000020680	Apoptosis, caspase activation inhibitor.	Apoptotic peptidase activating factor 1.	0.977
aven	ENSHCOP00000023803	ENSHCOP00000019805	ENSHCOP00000023803	Apoptosis, caspase activation inhibitor.	Uncharacterized protein.	0.810
aven	LOC109516977	ENSHCOP00000019805	ENSHCOP00000003779	Apoptosis, caspase activation inhibitor.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.699
aven	WDR7	ENSHCOP00000019805	ENSHCOP00000001833	Apoptosis, caspase activation inhibitor.	WD repeat domain 7.	0.537

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.95

expected number of edges:

33

PPI enrichment p-value:

0.159

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 32

1.27

0.7

0.0247

GO:0044281

Small molecule metabolic process

10 of 316

0.67

0.55

0.00064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1503

Mixed, incl. EAL domain, and tRNA synthetases class II (A)

5 of 13

1.76

2.12

1.41e-05

CL:1504

Mixed, incl. EAL domain, and Naphthalene degradation

3 of 7

1.81

1.29

0.0024

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00071

Fatty acid degradation

4 of 9

1.82

1.91

7.55e-05

map00626

Naphthalene degradation

3 of 7

1.81

1.4

0.0013

map00350

Tyrosine metabolism

3 of 10

1.65

1.25

0.0021

map01220

Degradation of aromatic compounds

3 of 13

1.54

1.14

0.0030

map00625

Chloroalkane and chloroalkene degradation

3 of 13

1.54

1.14

0.0030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005835

Fatty acid synthase complex

2 of 2

2.17

0.74

0.0437

GOCC:0005737

Cytoplasm

9 of 474

0.45

0.29

0.0437

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 18

1.4

0.64

0.0444

KW-0808

Transferase

7 of 238

0.64

0.38

0.0444

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