NEMF protein (Hippocampus comes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NEMF

Nuclear export mediator factor. (1056 aa)

Predicted Functional Partners:

ltn1

0.964

rpl11

0.888

rpl23

0.880

rpl23a

0.876

rpl35

0.869

rpl13a

0.857

mrpl13

0.857

rpl8

0.854

ENSHCOP00000012955

0.847

rpl9

0.847

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000012955	NEMF	ENSHCOP00000012955	ENSHCOP00000024153	Uncharacterized protein.	Nuclear export mediator factor.	0.847
ENSHCOP00000012955	ltn1	ENSHCOP00000012955	ENSHCOP00000014396	Uncharacterized protein.	Listerin E3 ubiquitin protein ligase 1.	0.591
ENSHCOP00000012955	mrpl13	ENSHCOP00000012955	ENSHCOP00000009580	Uncharacterized protein.	Mitochondrial ribosomal protein L13.	0.984
ENSHCOP00000012955	rpl11	ENSHCOP00000012955	ENSHCOP00000006666	Uncharacterized protein.	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.	0.994
ENSHCOP00000012955	rpl13a	ENSHCOP00000012955	ENSHCOP00000006148	Uncharacterized protein.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.995
ENSHCOP00000012955	rpl23	ENSHCOP00000012955	ENSHCOP00000005940	Uncharacterized protein.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.994
ENSHCOP00000012955	rpl23a	ENSHCOP00000012955	ENSHCOP00000006196	Uncharacterized protein.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.996
ENSHCOP00000012955	rpl35	ENSHCOP00000012955	ENSHCOP00000000783	Uncharacterized protein.	60S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family.	0.996
ENSHCOP00000012955	rpl8	ENSHCOP00000012955	ENSHCOP00000024707	Uncharacterized protein.	Ribosomal protein L8.	0.993
NEMF	ENSHCOP00000012955	ENSHCOP00000024153	ENSHCOP00000012955	Nuclear export mediator factor.	Uncharacterized protein.	0.847
NEMF	ltn1	ENSHCOP00000024153	ENSHCOP00000014396	Nuclear export mediator factor.	Listerin E3 ubiquitin protein ligase 1.	0.964
NEMF	mrpl13	ENSHCOP00000024153	ENSHCOP00000009580	Nuclear export mediator factor.	Mitochondrial ribosomal protein L13.	0.857
NEMF	rpl11	ENSHCOP00000024153	ENSHCOP00000006666	Nuclear export mediator factor.	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.	0.888
NEMF	rpl13a	ENSHCOP00000024153	ENSHCOP00000006148	Nuclear export mediator factor.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.857
NEMF	rpl23	ENSHCOP00000024153	ENSHCOP00000005940	Nuclear export mediator factor.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.880
NEMF	rpl23a	ENSHCOP00000024153	ENSHCOP00000006196	Nuclear export mediator factor.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.876
NEMF	rpl35	ENSHCOP00000024153	ENSHCOP00000000783	Nuclear export mediator factor.	60S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family.	0.869
NEMF	rpl8	ENSHCOP00000024153	ENSHCOP00000024707	Nuclear export mediator factor.	Ribosomal protein L8.	0.854
NEMF	rpl9	ENSHCOP00000024153	ENSHCOP00000018096	Nuclear export mediator factor.	Ribosomal protein L9.	0.847
ltn1	ENSHCOP00000012955	ENSHCOP00000014396	ENSHCOP00000012955	Listerin E3 ubiquitin protein ligase 1.	Uncharacterized protein.	0.591

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

26

PPI enrichment p-value:

9.76e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000271

Polysaccharide biosynthetic process

8 of 26

1.8

3.63

1.55e-10

GO:0033692

Cellular polysaccharide biosynthetic process

4 of 18

1.66

1.6

0.00025

GO:0009059

Macromolecule biosynthetic process

10 of 204

1.01

1.19

1.05e-07

GO:0034645

Cellular macromolecule biosynthetic process

7 of 156

0.97

0.88

0.00025

GO:1901137

Carbohydrate derivative biosynthetic process

5 of 119

0.94

0.63

0.0107

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 551

0.53

0.39

0.0064

GO:0016020

Membrane

10 of 703

0.47

0.35

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2267

Polysaccharide biosynthetic process, and Glycoprotein metabolic process

8 of 14

2.07

5.07

7.22e-13

CL:2265

Polysaccharide biosynthetic process, and Glycosyl transferases group 1

9 of 25

1.87

4.5

3.11e-13

CL:2269

Mixed, incl. Cell aggregation, and Polysaccharide biosynthesis protein

5 of 5

2.31

3.84

1.87e-08

CL:2283

Protein tyrosine kinase activity, and Capsule organization

2 of 6

1.84

0.72

0.0417

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02397

Bacterial sugar transferase

2 of 2

2.31

0.75

0.0425

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