E0L32_008468 protein (Phialemoniopsis curvata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

E0L32_008468

Uncharacterized protein. (460 aa)

Predicted Functional Partners:

E0L32_002398

0.999

E0L32_009516

0.999

E0L32_005697

0.999

E0L32_003025

0.999

E0L32_000528

0.999

E0L32_001061

0.998

E0L32_011681

0.998

E0L32_012038

0.998

E0L32_006425

0.997

E0L32_004334

0.997

Your Current Organism:

Phialemoniopsis curvata

NCBI taxonomy Id: 1093900
Other names: Bionectriaceae sp. NRRL 46124, CBS 490.82, CDC 45-394-63, P. curvata, Phialemoniopsis curvata (W. Gams & W. B. Cooke) H. Perdomo, D. Garca, Gen, Cano & Guarro 2013, Phialemonium curvatum, Xylariales sp. HP-2011b

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0L32_000528	E0L32_001061	A0A507B5Z0	A0A507AU22	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_000528	E0L32_002398	A0A507B5Z0	A0A507AEQ5	Rieske domain-containing protein.	Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.	0.999
E0L32_000528	E0L32_003025	A0A507B5Z0	A0A507B544	Rieske domain-containing protein.	Cytochrome c domain-containing protein.	0.999
E0L32_000528	E0L32_004334	A0A507B5Z0	A0A507B907	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_000528	E0L32_005697	A0A507B5Z0	A0A507B2N0	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_000528	E0L32_006425	A0A507B5Z0	A0A507AQT6	Rieske domain-containing protein.	Uncharacterized protein.	0.998
E0L32_000528	E0L32_008468	A0A507B5Z0	A0A507ALI9	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_000528	E0L32_009516	A0A507B5Z0	A0A507AS24	Rieske domain-containing protein.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.999
E0L32_000528	E0L32_011681	A0A507B5Z0	A0A507BEL7	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_000528	E0L32_012038	A0A507B5Z0	A0A507BJT4	Rieske domain-containing protein.	Uncharacterized protein.	0.999
E0L32_001061	E0L32_000528	A0A507AU22	A0A507B5Z0	Uncharacterized protein.	Rieske domain-containing protein.	0.999
E0L32_001061	E0L32_002398	A0A507AU22	A0A507AEQ5	Uncharacterized protein.	Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.	0.999
E0L32_001061	E0L32_003025	A0A507AU22	A0A507B544	Uncharacterized protein.	Cytochrome c domain-containing protein.	0.999
E0L32_001061	E0L32_004334	A0A507AU22	A0A507B907	Uncharacterized protein.	Uncharacterized protein.	0.999
E0L32_001061	E0L32_005697	A0A507AU22	A0A507B2N0	Uncharacterized protein.	Uncharacterized protein.	0.999
E0L32_001061	E0L32_006425	A0A507AU22	A0A507AQT6	Uncharacterized protein.	Uncharacterized protein.	0.996
E0L32_001061	E0L32_008468	A0A507AU22	A0A507ALI9	Uncharacterized protein.	Uncharacterized protein.	0.998
E0L32_001061	E0L32_009516	A0A507AU22	A0A507AS24	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.998
E0L32_001061	E0L32_011681	A0A507AU22	A0A507BEL7	Uncharacterized protein.	Uncharacterized protein.	0.999
E0L32_001061	E0L32_012038	A0A507AU22	A0A507BJT4	Uncharacterized protein.	Uncharacterized protein.	0.997

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.527

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048284

Organelle fusion

9 of 42

2.12

5.88

5.82e-15

GO:0007033

Vacuole organization

7 of 39

2.05

4.21

1.96e-10

GO:0016050

Vesicle organization

7 of 47

1.96

3.92

4.31e-10

GO:0034058

Endosomal vesicle fusion

4 of 4

2.79

3.84

7.14e-08

GO:0006906

Vesicle fusion

5 of 26

2.08

3.25

1.13e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030897

HOPS complex

6 of 6

2.79

6.12

2.31e-12

GO:0099023

Vesicle tethering complex

7 of 42

2.01

4.33

5.16e-11

GO:0033263

CORVET complex

4 of 4

2.79

4.06

2.76e-08

GO:0005768

Endosome

9 of 114

1.69

3.63

3.04e-12

GO:0005770

Late endosome

4 of 30

1.92

2.31

1.14e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5225

HOPS complex, and Endosomal vesicle fusion

9 of 11

2.7

9.41

1.20e-19

CL:5223

RAB geranylgeranylation, and HOPS complex

10 of 31

2.3

8.06

1.20e-19

CL:5130

Mixed, incl. Vesicle tethering complex, and Membrane fusion

11 of 90

1.88

5.63

1.23e-18

CL:5227

HOPS complex

5 of 5

2.79

5.26

1.19e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04138

Autophagy - yeast

7 of 78

1.74

3.23

1.63e-09

map04145

Phagosome

3 of 52

1.55

1.04

0.0055

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

5 of 31

2.0

2.76

1.24e-06

MAP-1643685

Disease

5 of 40

1.89

2.56

2.00e-06

MAP-8873719

RAB geranylgeranylation

3 of 16

2.06

1.57

0.00089

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030897

HOPS complex

7 of 8

2.73

7.13

1.40e-14

GOCC:0042597

Periplasmic space

2 of 5

2.39

1.11

0.0089

GOCC:0016020

Membrane

8 of 964

0.71

0.53

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000547

Clathrin, heavy chain/VPS, 7-fold repeat

4 of 5

2.69

3.22

9.97e-07

IPR045111

Vacuolar protein sorting-associated protein Vps41/Vps8

2 of 2

2.79

1.0

0.0153

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00175

Rab subfamily of small GTPases

2 of 10

2.09

0.9

0.0205

SM00184

Ring finger

3 of 50

1.57

0.84

0.0186

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