E0L32_005160 protein (Phialemoniopsis curvata)

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

E0L32_005160

Uncharacterized protein. (347 aa)

Predicted Functional Partners:

E0L32_008860

0.636

E0L32_011410

0.636

E0L32_006697

0.568

E0L32_010426

0.546

E0L32_004915

0.516

E0L32_003250

0.507

E0L32_010929

0.472

E0L32_007661

0.459

E0L32_008799

0.455

E0L32_010716

0.454

Your Current Organism:

Phialemoniopsis curvata

NCBI taxonomy Id: 1093900
Other names: Bionectriaceae sp. NRRL 46124, CBS 490.82, CDC 45-394-63, P. curvata, Phialemoniopsis curvata (W. Gams & W. B. Cooke) H. Perdomo, D. Garca, Gen, Cano & Guarro 2013, Phialemonium curvatum, Xylariales sp. HP-2011b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0L32_003250	E0L32_004915	A0A507B4E6	A0A507AWD3	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.470
E0L32_003250	E0L32_005160	A0A507B4E6	A0A507AVE2	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.507
E0L32_003250	E0L32_008860	A0A507B4E6	A0A507AQF3	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.739
E0L32_003250	E0L32_010426	A0A507B4E6	A0A507ASG7	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.832
E0L32_003250	E0L32_011410	A0A507B4E6	A0A507B9D1	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.739
E0L32_004915	E0L32_003250	A0A507AWD3	A0A507B4E6	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.470
E0L32_004915	E0L32_005160	A0A507AWD3	A0A507AVE2	Uncharacterized protein.	Uncharacterized protein.	0.516
E0L32_004915	E0L32_006697	A0A507AWD3	A0A507AZ69	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.453
E0L32_004915	E0L32_008860	A0A507AWD3	A0A507AQF3	Uncharacterized protein.	Uncharacterized protein.	0.516
E0L32_004915	E0L32_010426	A0A507AWD3	A0A507ASG7	Uncharacterized protein.	Uncharacterized protein.	0.516
E0L32_004915	E0L32_011410	A0A507AWD3	A0A507B9D1	Uncharacterized protein.	Uncharacterized protein.	0.516
E0L32_005160	E0L32_003250	A0A507AVE2	A0A507B4E6	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.507
E0L32_005160	E0L32_004915	A0A507AVE2	A0A507AWD3	Uncharacterized protein.	Uncharacterized protein.	0.516
E0L32_005160	E0L32_006697	A0A507AVE2	A0A507AZ69	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.568
E0L32_005160	E0L32_007661	A0A507AVE2	A0A507AP53	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.459
E0L32_005160	E0L32_008799	A0A507AVE2	A0A507AK83	Uncharacterized protein.	Uncharacterized protein.	0.455
E0L32_005160	E0L32_008860	A0A507AVE2	A0A507AQF3	Uncharacterized protein.	Uncharacterized protein.	0.636
E0L32_005160	E0L32_010426	A0A507AVE2	A0A507ASG7	Uncharacterized protein.	Uncharacterized protein.	0.546
E0L32_005160	E0L32_010716	A0A507AVE2	A0A507AKR9	Uncharacterized protein.	Uncharacterized protein.	0.454
E0L32_005160	E0L32_010929	A0A507AVE2	A0A507AQG9	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.472

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

18

PPI enrichment p-value:

4.38e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

6 of 54

2.02

3.34

4.27e-08

GO:0046856

Phosphatidylinositol dephosphorylation

3 of 9

2.5

2.2

7.88e-05

GO:0006661

Phosphatidylinositol biosynthetic process

4 of 44

1.93

2.03

6.04e-05

GO:0046854

Phosphatidylinositol phosphate biosynthetic process

3 of 15

2.27

1.97

0.00017

GO:0006914

Autophagy

4 of 57

1.82

1.86

0.00010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

3 of 9

2.5

1.92

0.00027

GO:0052744

Phosphatidylinositol monophosphate phosphatase activity

2 of 3

2.8

1.19

0.0071

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 381

1.09

0.71

0.0125

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 266

1.15

0.57

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035032

Phosphatidylinositol 3-kinase complex, class III

5 of 7

2.83

5.09

2.85e-10

GO:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

3 of 3

2.97

2.99

3.45e-06

GO:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

3 of 3

2.97

2.99

3.45e-06

GO:0000407

Phagophore assembly site

3 of 20

2.15

1.96

0.00015

GO:0005768

Endosome

5 of 124

1.58

1.9

1.56e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13019

Mixed, incl. Inositol phosphate metabolism, and Autophagy - other

9 of 86

1.99

5.22

2.64e-14

CL:13028

Autophagy - other

5 of 22

2.33

3.77

2.91e-08

CL:13123

Inositol phosphate metabolism

4 of 23

2.21

2.77

3.11e-06

CL:13125

Inositol phosphate metabolism

3 of 17

2.22

1.92

0.00020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00562

Inositol phosphate metabolism

6 of 37

2.18

4.45

2.37e-10

map04136

Autophagy - other

4 of 25

2.18

3.01

7.86e-07

map04070

Phosphatidylinositol signaling system

5 of 57

1.92

2.94

2.14e-07

map04138

Autophagy - yeast

5 of 108

1.64

2.21

2.27e-06

map04145

Phagosome

3 of 84

1.53

1.15

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1660516

Synthesis of PIPs at the early endosome membrane

6 of 11

2.71

5.99

3.03e-12

MAP-1660517

Synthesis of PIPs at the late endosome membrane

5 of 8

2.77

5.16

1.81e-10

MAP-1483255

PI Metabolism

6 of 28

2.3

4.71

1.64e-10

MAP-9612973

Autophagy

6 of 59

1.98

3.64

3.97e-09

MAP-1632852

Macroautophagy

6 of 59

1.98

3.64

3.97e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035032

Phosphatidylinositol 3-kinase complex, class III

6 of 10

2.75

6.12

1.98e-12

GOCC:0034272

Phosphatidylinositol 3-kinase complex, class III, type II

4 of 4

2.97

4.32

1.11e-08

GOCC:0034271

Phosphatidylinositol 3-kinase complex, class III, type I

3 of 3

2.97

3.05

2.73e-06

GOCC:0070772

PAS complex

2 of 6

2.5

1.38

0.0029

GOCC:0016020

Membrane

7 of 1201

0.74

0.54

0.0052

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02383

SacI homology domain

2 of 4

2.67

1.02

0.0140

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002013

SAC domain

2 of 4

2.67

0.77

0.0401

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