STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
E0L32_000040Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (721 aa)    
Predicted Functional Partners:
E0L32_010959
Autophagy-related protein.
   
 0.997
E0L32_004986
Autophagy-related protein 3.
  
 
 0.997
E0L32_011461
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
    
 0.987
E0L32_001106
Uncharacterized protein.
   
 0.980
E0L32_006697
UBIQUITIN_CONJUGAT_2 domain-containing protein.
  
 0.978
E0L32_011491
HECT domain-containing protein.
    
 0.967
E0L32_011581
Lipase_3 domain-containing protein.
   
 
 0.961
E0L32_003501
Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
    
 0.924
E0L32_006440
Uncharacterized protein.
    
 0.917
E0L32_001034
Autophagy_act_C domain-containing protein.
    
 0.913
Your Current Organism:
Phialemoniopsis curvata
NCBI taxonomy Id: 1093900
Other names: Bionectriaceae sp. NRRL 46124, CBS 490.82, CDC 45-394-63, P. curvata, Phialemoniopsis curvata (W. Gams & W. B. Cooke) H. Perdomo, D. Garca, Gen, Cano & Guarro 2013, Phialemonium curvatum, Xylariales sp. HP-2011b
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