E0L32_003674 protein (Phialemoniopsis curvata)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

E0L32_003674

Uncharacterized protein. (549 aa)

Predicted Functional Partners:

E0L32_002585

0.923

E0L32_006248

0.915

E0L32_008458

0.881

E0L32_005568

0.853

E0L32_008491

0.843

E0L32_010541

0.839

E0L32_009741

0.811

E0L32_002702

0.779

E0L32_005375

0.756

E0L32_008175

0.748

Your Current Organism:

Phialemoniopsis curvata

NCBI taxonomy Id: 1093900
Other names: Bionectriaceae sp. NRRL 46124, CBS 490.82, CDC 45-394-63, P. curvata, Phialemoniopsis curvata (W. Gams & W. B. Cooke) H. Perdomo, D. Garca, Gen, Cano & Guarro 2013, Phialemonium curvatum, Xylariales sp. HP-2011b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0L32_002585	E0L32_003674	A0A507BPK0	A0A507BB12	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.923
E0L32_002585	E0L32_005375	A0A507BPK0	A0A507BBK3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	WD_REPEATS_REGION domain-containing protein.	0.997
E0L32_002585	E0L32_005568	A0A507BPK0	A0A507AWM7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.997
E0L32_002585	E0L32_008175	A0A507BPK0	A0A507B122	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Rap-GAP domain-containing protein.	0.913
E0L32_002585	E0L32_008458	A0A507BPK0	A0A507ALI2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.628
E0L32_002585	E0L32_008491	A0A507BPK0	A0A507AJS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.606
E0L32_002585	E0L32_009741	A0A507BPK0	A0A507AV57	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.933
E0L32_002585	E0L32_010541	A0A507BPK0	A0A507AS88	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	WD_REPEATS_REGION domain-containing protein.	0.998
E0L32_002702	E0L32_003674	A0A507BFC4	A0A507BB12	HRDC domain-containing protein.	Uncharacterized protein.	0.779
E0L32_002702	E0L32_005375	A0A507BFC4	A0A507BBK3	HRDC domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.979
E0L32_002702	E0L32_005568	A0A507BFC4	A0A507AWM7	HRDC domain-containing protein.	Uncharacterized protein.	0.974
E0L32_002702	E0L32_008175	A0A507BFC4	A0A507B122	HRDC domain-containing protein.	Rap-GAP domain-containing protein.	0.865
E0L32_002702	E0L32_008458	A0A507BFC4	A0A507ALI2	HRDC domain-containing protein.	Protein kinase domain-containing protein.	0.453
E0L32_002702	E0L32_008491	A0A507BFC4	A0A507AJS1	HRDC domain-containing protein.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.545
E0L32_002702	E0L32_009741	A0A507BFC4	A0A507AV57	HRDC domain-containing protein.	Uncharacterized protein.	0.546
E0L32_002702	E0L32_010541	A0A507BFC4	A0A507AS88	HRDC domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.980
E0L32_003674	E0L32_002585	A0A507BB12	A0A507BPK0	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.923
E0L32_003674	E0L32_002702	A0A507BB12	A0A507BFC4	Uncharacterized protein.	HRDC domain-containing protein.	0.779
E0L32_003674	E0L32_005375	A0A507BB12	A0A507BBK3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.756
E0L32_003674	E0L32_005568	A0A507BB12	A0A507AWM7	Uncharacterized protein.	Uncharacterized protein.	0.853

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

33

PPI enrichment p-value:

0.000683

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 25

1.88

3.02

8.67e-08

GO:0007165

Signal transduction

6 of 58

1.51

1.99

2.83e-06

GO:0050896

Response to stimulus

11 of 236

1.17

1.71

2.41e-10

GO:0000160

Phosphorelay signal transduction system

3 of 46

1.31

0.69

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 26

1.93

3.76

7.90e-10

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 143

1.3

1.96

4.11e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 671

0.63

0.49

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3210

PAS-associated, C-terminal, and cheY-homologous receiver domain

10 of 15

2.32

7.99

3.66e-19

CL:3213

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Cell pole

8 of 10

2.4

6.93

1.56e-15

CL:3205

Signal transduction, and PAS fold-4

11 of 34

2.01

6.46

3.66e-19

CL:3216

PAS-associated, C-terminal, and WD40/YVTN repeat-like-containing domain superfamily

5 of 5

2.5

4.5

1.57e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 255

1.09

1.44

7.16e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 46

1.79

4.18

3.52e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011006

CheY-like superfamily

9 of 37

1.88

4.53

3.88e-13

IPR001789

Signal transduction response regulator, receiver domain

9 of 37

1.88

4.53

3.88e-13

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 21

2.02

4.21

1.40e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 22

2.0

4.16

1.40e-10

IPR005467

Histidine kinase domain

7 of 24

1.96

4.03

1.85e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 35

1.91

4.91

2.15e-14

SM00388

His Kinase A (phosphoacceptor) domain

7 of 22

2.0

4.4

2.37e-11

SM00387

Histidine kinase-like ATPases

7 of 26

1.93

4.13

4.31e-11

SM00091

PAS domain

3 of 10

1.98

1.84

0.00019

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 5

2.1

1.24

0.0043

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