E0L32_003289 protein (Phialemoniopsis curvata)

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

E0L32_003289

Uncharacterized protein. (1737 aa)

Predicted Functional Partners:

E0L32_006251

0.833

E0L32_011218

0.607

E0L32_007308

0.602

E0L32_009237

0.601

E0L32_003032

0.568

E0L32_000181

0.564

E0L32_001814

0.551

E0L32_001342

0.542

E0L32_009471

0.538

E0L32_004799

0.534

Your Current Organism:

Phialemoniopsis curvata

NCBI taxonomy Id: 1093900
Other names: Bionectriaceae sp. NRRL 46124, CBS 490.82, CDC 45-394-63, P. curvata, Phialemoniopsis curvata (W. Gams & W. B. Cooke) H. Perdomo, D. Garca, Gen, Cano & Guarro 2013, Phialemonium curvatum, Xylariales sp. HP-2011b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E0L32_000181	E0L32_001342	A0A507B7S1	A0A507AIU4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.997
E0L32_000181	E0L32_003032	A0A507B7S1	A0A507BIY5	Uncharacterized protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
E0L32_000181	E0L32_003289	A0A507B7S1	A0A507BJE3	Uncharacterized protein.	Uncharacterized protein.	0.564
E0L32_000181	E0L32_006251	A0A507B7S1	A0A507B919	Uncharacterized protein.	RanBD1 domain-containing protein.	0.999
E0L32_001342	E0L32_000181	A0A507AIU4	A0A507B7S1	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.997
E0L32_001342	E0L32_001814	A0A507AIU4	A0A507AVM2	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	UBA domain-containing protein.	0.413
E0L32_001342	E0L32_003032	A0A507AIU4	A0A507BIY5	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.997
E0L32_001342	E0L32_003289	A0A507AIU4	A0A507BJE3	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.542
E0L32_001342	E0L32_006251	A0A507AIU4	A0A507B919	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	RanBD1 domain-containing protein.	0.999
E0L32_001814	E0L32_001342	A0A507AVM2	A0A507AIU4	UBA domain-containing protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.413
E0L32_001814	E0L32_003289	A0A507AVM2	A0A507BJE3	UBA domain-containing protein.	Uncharacterized protein.	0.551
E0L32_001814	E0L32_007308	A0A507AVM2	A0A507AMQ9	UBA domain-containing protein.	B30.2/SPRY domain-containing protein.	0.679
E0L32_001814	E0L32_011218	A0A507AVM2	A0A507BGG3	UBA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.681
E0L32_003032	E0L32_000181	A0A507BIY5	A0A507B7S1	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Uncharacterized protein.	0.999
E0L32_003032	E0L32_001342	A0A507BIY5	A0A507AIU4	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.997
E0L32_003032	E0L32_003289	A0A507BIY5	A0A507BJE3	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Uncharacterized protein.	0.568
E0L32_003032	E0L32_006251	A0A507BIY5	A0A507B919	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	RanBD1 domain-containing protein.	0.999
E0L32_003289	E0L32_000181	A0A507BJE3	A0A507B7S1	Uncharacterized protein.	Uncharacterized protein.	0.564
E0L32_003289	E0L32_001342	A0A507BJE3	A0A507AIU4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.542
E0L32_003289	E0L32_001814	A0A507BJE3	A0A507AVM2	Uncharacterized protein.	UBA domain-containing protein.	0.551

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

5.38e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006271

DNA strand elongation involved in DNA replication

6 of 23

2.4

5.03

6.28e-11

GO:0006261

DNA-templated DNA replication

8 of 73

2.03

4.9

8.87e-13

GO:0006260

DNA replication

9 of 103

1.93

4.82

1.11e-13

GO:0006281

DNA repair

10 of 233

1.62

3.5

3.96e-13

GO:0006259

DNA metabolic process

11 of 331

1.51

3.12

1.11e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003677

DNA binding

10 of 644

1.18

1.62

1.16e-08

GO:0140097

Catalytic activity, acting on DNA

5 of 146

1.52

1.58

0.00012

GO:0004527

Exonuclease activity

3 of 35

1.92

1.42

0.0015

GO:0140640

Catalytic activity, acting on a nucleic acid

6 of 398

1.17

1.1

0.00030

GO:0003676

Nucleic acid binding

11 of 1266

0.93

1.06

5.51e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005657

Replication fork

7 of 36

2.28

5.37

2.80e-12

GO:0031391

Elg1 RFC-like complex

4 of 4

2.99

4.21

1.78e-08

GO:0005663

DNA replication factor C complex

4 of 5

2.89

4.15

2.13e-08

GO:0031389

Rad17 RFC-like complex

3 of 4

2.86

2.9

4.74e-06

GO:0031390

Ctf18 RFC-like complex

3 of 5

2.76

2.82

6.32e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6245

Lagging Strand Synthesis, and Error-free translesion synthesis

9 of 29

2.48

8.46

6.83e-19

CL:6246

Mixed, incl. Polymerase switching, and ATP dependent DNA ligase domain

8 of 18

2.63

8.33

1.46e-17

CL:6180

Mixed, incl. Mismatch repair, and HDR through Homologous Recombination (HRR)

11 of 72

2.17

7.8

5.97e-21

CL:6181

Mixed, incl. Homologous recombination, and Postreplication repair

10 of 61

2.2

7.39

6.04e-19

CL:6247

Mixed, incl. Ctf18 RFC-like complex, and DNA clamp loader activity

5 of 12

2.61

4.86

4.25e-10

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

8 of 50

2.19

6.01

1.16e-14

map03030

DNA replication

8 of 67

2.06

5.39

5.09e-14

map03420

Nucleotide excision repair

7 of 67

2.01

4.53

9.61e-12

map03410

Base excision repair

4 of 41

1.98

2.56

3.46e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69186

Lagging Strand Synthesis

8 of 35

2.35

6.58

5.28e-15

MAP-69190

DNA strand elongation

8 of 41

2.28

6.32

8.20e-15

MAP-69239

Synthesis of DNA

8 of 65

2.08

5.28

1.62e-13

MAP-69242

S Phase

8 of 68

2.06

5.21

1.70e-13

MAP-69306

DNA Replication

8 of 78

2.0

4.92

3.82e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031389

Rad17 RFC-like complex

3 of 4

2.86

2.61

1.64e-05

GOCC:0005663

DNA replication factor C complex

3 of 4

2.86

2.61

1.64e-05

GOCC:0005657

Replication fork

4 of 26

2.17

2.42

1.64e-05

GOCC:0031391

Elg1 RFC-like complex

2 of 3

2.81

1.5

0.0019

GOCC:0031390

Ctf18 RFC-like complex

2 of 5

2.59

1.35

0.0034

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

4 of 26

2.17

2.7

3.95e-06

KW-0234

DNA repair

3 of 22

2.12

1.87

0.00022

KW-0238

DNA-binding

3 of 161

1.26

0.66

0.0321

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08542

Replication factor C C-terminal domain

3 of 3

2.99

2.62

1.70e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008921

DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal

4 of 6

2.81

3.48

3.72e-07

IPR013748

Replication factor C, C-terminal

3 of 3

2.99

2.54

2.37e-05

IPR003593

AAA+ ATPase domain

4 of 121

1.51

1.03

0.0054

IPR003959

ATPase, AAA-type, core

3 of 51

1.76

0.93

0.0143

IPR043502

DNA/RNA polymerase superfamily

2 of 13

2.17

0.71

0.0490

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 122

1.5

1.18

0.0020

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