STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tsac_0044KEGG: txy:Thexy_1941 glutamate formiminotransferase; TIGRFAM: Formiminotransferase; PFAM: Formiminotransferase, N-terminal; Formiminotransferase, C-terminal. (298 aa)    
Predicted Functional Partners:
Tsac_0043
Formiminotransferase-cyclodeaminase; PFAM: Cyclodeaminase/cyclohydrolase; KEGG: txy:Thexy_1940 methenyltetrahydrofolate cyclohydrolase.
 
  0.999
fhs
KEGG: txy:Thexy_0263 Formate--tetrahydrofolate ligase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; PFAM: Formate-tetrahydrofolate ligase, FTHFS.
    
  0.922
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
  
  0.911
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
  0.906
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
    
  0.901
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
  0.900
Tsac_1397
PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: txy:Thexy_1842 methionine synthase.
     
  0.900
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
     
  0.900
purH
SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: txy:Thexy_0714 Bifunctional purine biosynthesis protein PurH; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like.
     
  0.900
Tsac_2085
KEGG: txy:Thexy_1543 glutamate synthase (NADPH), homotetrameric; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region.
  
  
  0.828
Your Current Organism:
Thermoanaerobacterium saccharolyticum
NCBI taxonomy Id: 1094508
Other names: T. saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum str. JW/SL-YS485, Thermoanaerobacterium saccharolyticum strain JW/SL-YS485, Thermoanaerobacterium sp. (strain JW/SL YS485)
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