STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Tsac_0188Phage repressor like transcriptional regulator, XRE family; KEGG: chy:CHY_1697 putative prophage LambdaCh01, repressor protein; PFAM: Peptidase S24/S26A/S26B, conserved region; Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; Belongs to the peptidase S24 family. (273 aa)    
Predicted Functional Partners:
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.919
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.840
Tsac_0189
Integrase family protein; PFAM: Integrase, catalytic core, phage; KEGG: cki:Calkr_0670 integrase family protein; Belongs to the 'phage' integrase family.
  
  
 0.804
cinA
KEGG: txy:Thexy_1268 competence/damage-inducible protein CinA; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; Belongs to the CinA family.
     
 0.746
birA
BirA bifunctional protein, biotin operon repressor, biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.602
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.601
Tsac_1988
Helix-turn-helix domain protein; KEGG: tit:Thit_2376 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3.
  
  
 0.582
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.560
Tsac_0185
PFAM: SNF2-related.
  
    0.516
Tsac_0186
PFAM: SNF2-related; KEGG: stc:str0237 ATP-dependent RNA helicase.
  
    0.504
Your Current Organism:
Thermoanaerobacterium saccharolyticum
NCBI taxonomy Id: 1094508
Other names: T. saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum str. JW/SL-YS485, Thermoanaerobacterium saccharolyticum strain JW/SL-YS485, Thermoanaerobacterium sp. (strain JW/SL YS485)
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