STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: txy:Thexy_1470 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 0.999
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 0.999
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: txy:Thexy_1469 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.999
Tsac_2014
KEGG: txy:Thexy_1472 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
  
 0.999
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 0.999
hisI
TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; KEGG: txy:Thexy_0452 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.709
Tsac_2008
PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: txy:Thexy_1466 Peroxiredoxin.
  
    0.557
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 
 0.554
birA
BirA bifunctional protein, biotin operon repressor, biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.534
Your Current Organism:
Thermoanaerobacterium saccharolyticum
NCBI taxonomy Id: 1094508
Other names: T. saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum str. JW/SL-YS485, Thermoanaerobacterium saccharolyticum strain JW/SL-YS485, Thermoanaerobacterium sp. (strain JW/SL YS485)
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