STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCPolC-type DNA polymerase III; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1439 aa)    
Predicted Functional Partners:
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.936
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.933
holA
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.922
APT14899.1
DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
0.916
APT14301.1
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.915
APT14496.1
Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
0.914
APT15229.1
DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.910
proS
proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
  
    0.834
rseP
RIP metalloprotease RseP; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.780
APT14593.1
Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.768
Your Current Organism:
Lactobacillus jensenii
NCBI taxonomy Id: 109790
Other names: ATCC 25258, CCUG 21961, CCUG 35572, CIP 69.17, DSM 20557, JCM 15953, L. jensenii, LMG 6414, LMG:6414, NRRL B-4550
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