node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CF8_0106 | arc | CF8_0106 | CF8_1967 | Hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.779 |
CF8_0106 | pafA | CF8_0106 | CF8_1975 | Hypothetical protein. | Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.678 |
CF8_0106 | prcA | CF8_0106 | CF8_1973 | Hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.999 |
CF8_0106 | prcB | CF8_0106 | CF8_1972 | Hypothetical protein. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.977 |
CF8_1974 | CF8_1976 | CF8_1974 | CF8_1976 | Endonuclease/exonuclease/phosphatase. | Peptidylprolyl isomerase, FKBP-type. | 0.552 |
CF8_1974 | CF8_1977 | CF8_1974 | CF8_1977 | Endonuclease/exonuclease/phosphatase. | Transcriptional regulator-like protein. | 0.485 |
CF8_1974 | CF8_1978 | CF8_1974 | CF8_1978 | Endonuclease/exonuclease/phosphatase. | Hypothetical protein. | 0.431 |
CF8_1974 | pafA | CF8_1974 | CF8_1975 | Endonuclease/exonuclease/phosphatase. | Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.762 |
CF8_1974 | prcA | CF8_1974 | CF8_1973 | Endonuclease/exonuclease/phosphatase. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.773 |
CF8_1974 | prcB | CF8_1974 | CF8_1972 | Endonuclease/exonuclease/phosphatase. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.752 |
CF8_1976 | CF8_1974 | CF8_1976 | CF8_1974 | Peptidylprolyl isomerase, FKBP-type. | Endonuclease/exonuclease/phosphatase. | 0.552 |
CF8_1976 | CF8_1977 | CF8_1976 | CF8_1977 | Peptidylprolyl isomerase, FKBP-type. | Transcriptional regulator-like protein. | 0.706 |
CF8_1976 | CF8_1978 | CF8_1976 | CF8_1978 | Peptidylprolyl isomerase, FKBP-type. | Hypothetical protein. | 0.632 |
CF8_1976 | pafA | CF8_1976 | CF8_1975 | Peptidylprolyl isomerase, FKBP-type. | Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.675 |
CF8_1976 | prcA | CF8_1976 | CF8_1973 | Peptidylprolyl isomerase, FKBP-type. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.691 |
CF8_1976 | prcB | CF8_1976 | CF8_1972 | Peptidylprolyl isomerase, FKBP-type. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.681 |
CF8_1977 | CF8_1974 | CF8_1977 | CF8_1974 | Transcriptional regulator-like protein. | Endonuclease/exonuclease/phosphatase. | 0.485 |
CF8_1977 | CF8_1976 | CF8_1977 | CF8_1976 | Transcriptional regulator-like protein. | Peptidylprolyl isomerase, FKBP-type. | 0.706 |
CF8_1977 | CF8_1978 | CF8_1977 | CF8_1978 | Transcriptional regulator-like protein. | Hypothetical protein. | 0.993 |
CF8_1977 | pafA | CF8_1977 | CF8_1975 | Transcriptional regulator-like protein. | Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.716 |