| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CF8_2291 | CF8_2294 | CF8_2291 | CF8_2294 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Hypothetical protein. | 0.783 |
| CF8_2291 | CF8_3153 | CF8_2291 | CF8_3153 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Cystathionine beta-synthase. | 0.804 |
| CF8_2291 | coaA | CF8_2291 | CF8_0741 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase. | 0.933 |
| CF8_2291 | coaD | CF8_2291 | CF8_2881 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.962 |
| CF8_2291 | coaE | CF8_2291 | CF8_2531 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.854 |
| CF8_2291 | coaX | CF8_2291 | CF8_0385 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.933 |
| CF8_2291 | dut | CF8_2291 | CF8_2398 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.931 |
| CF8_2291 | gmk | CF8_2291 | CF8_2293 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.875 |
| CF8_2291 | panC | CF8_2291 | CF8_0381 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.884 |
| CF8_2291 | rpoZ | CF8_2291 | CF8_2292 | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.857 |
| CF8_2294 | CF8_2291 | CF8_2294 | CF8_2291 | Hypothetical protein. | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.783 |
| CF8_2294 | gmk | CF8_2294 | CF8_2293 | Hypothetical protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.870 |
| CF8_2294 | rpoZ | CF8_2294 | CF8_2292 | Hypothetical protein. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.972 |
| CF8_3153 | CF8_2291 | CF8_3153 | CF8_2291 | Cystathionine beta-synthase. | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.804 |
| CF8_3153 | dut | CF8_3153 | CF8_2398 | Cystathionine beta-synthase. | Deoxyuridine 5'-triphosphate; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.405 |
| CF8_3153 | gmk | CF8_3153 | CF8_2293 | Cystathionine beta-synthase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.468 |
| coaA | CF8_2291 | CF8_0741 | CF8_2291 | Pantothenate kinase. | Bifunctional phosphopantothenoylcysteine; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.933 |
| coaA | coaD | CF8_0741 | CF8_2881 | Pantothenate kinase. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.901 |
| coaA | coaE | CF8_0741 | CF8_2531 | Pantothenate kinase. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.504 |
| coaA | coaX | CF8_0741 | CF8_0385 | Pantothenate kinase. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.861 |